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1.
Bioorg Khim ; 38(5): 629-36, 2012.
Article in Russian | MEDLINE | ID: mdl-23342497

ABSTRACT

A series of terpenophenol-chlorin conjugates where terpenophenolic fragment has amide bond with macrocycle of methylpheophorbide a, formed by amidation of 13(2)-ester group were obtained by interaction of methylpheophorbide a and ortho-aminomethyl derivatives of 2-isobornyl-4-methylphenol. The substances investigated ability to interact with the cell membrane was shown in blood erythrocytes surface structure with scanning electron microscope. The conjugates studied were established to have antioxidant and membrane protective properties resulted from inhibiting H2O2-induced erythrocytes hemolysis and decrease of lipid peroxidation secondary product accumulation.


Subject(s)
Erythrocyte Membrane/chemistry , Hemolysis/drug effects , Hydrocarbons, Chlorinated , Lipid Peroxidation/drug effects , Phenols , Terpenes , Animals , Chlorophyll/analogs & derivatives , Chlorophyll/chemistry , Hydrocarbons, Chlorinated/chemical synthesis , Hydrocarbons, Chlorinated/chemistry , Hydrocarbons, Chlorinated/pharmacology , Mice , Phenols/chemical synthesis , Phenols/chemistry , Phenols/pharmacology , Terpenes/chemical synthesis , Terpenes/chemistry , Terpenes/pharmacology
2.
Biofizika ; 57(6): 1008-13, 2012.
Article in Russian | MEDLINE | ID: mdl-23272581

ABSTRACT

Interrelations between the structure of the semi-synthetic phenolic antioxidants -- isobornylphenols and their surface active properties were studied in the chemical (the lecithin aggregation in hexane) and biological (the incubation with the blood erythrocytes) model systems. It has been shown that all studied compounds are able to affect the lecithin aggregation in hexane: the share of the main fraction of the L micelles decreases with increasing the share of particles of greater size. The effect substantially depends on hindered OH group and the presence of the intramolecular hydrogen bond in molecule. The cytotoxic properties of isobornylphenols (the concentration is 100 M) are predominantly due to the molecule structure. The interrelation between the aggregate size of the main fraction of L in the presence of the studied compounds and the discocyte share during mice blood erythrocyte incubation in their presence for 4 h is revealed. Thus, this provides the possibility to assume that the ability of the different biological active substances to affect the lecithin aggregation in non-polar solvent could be used as a model system for the initial assessment of their surface active properties.


Subject(s)
Antioxidants/chemistry , Phenols/chemistry , Surface Properties , Animals , Erythrocytes , Hexanes/chemistry , Hydrogen Bonding , Lecithins/chemistry , Mice , Micelles , Molecular Structure , Solvents/chemistry
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