ABSTRACT
The article highlights the problem of the relationship of the intestinal microbiome person with metabolic syndrome. Changes in bacterial intestinal proportions in obesity captured the attention of scientists around the world, especially in relation to their effect on the metabolism. Increasing the proportion of Firmicutes and Actinobacteria and decrease of Bacteroidetes associated with increased levels of serum lipopolysaccharides, insulin resistance, weight gain, and other co-morbid manifestations of the metabolic syndrome. The mechanisms, underlying this interdisciplinary problems, actively studied to optimize the prevention and treatment of obesity and type 2 diabetes.
Subject(s)
Intestines/microbiology , Metabolic Syndrome/microbiology , Microbiota , Obesity/microbiology , Animals , Humans , Metabolic Syndrome/therapy , Obesity/therapy , Prebiotics , Probiotics/administration & dosage , Probiotics/therapeutic useABSTRACT
The article presents the results of a survey of 62 patients with chronic hepatitis C and 103 patients with liver cirrhosis of viral etiology. Besides clinical parameters studied autonomic features by analysis of heart rate variability at rest and active orthostasis. Indicators of frequency and spectral analysis of heart rate in study patients with chronic hepatitis C and cirrhosis of viral etiology confirmed increase in sympathetic activity and weakening of parasympathetic activity in all respects, with the sympathetic influence of enhanced active orthostasis. Indices of regulatory systems of the autonomic nervous system (stress index and the index of autonomic regulation) also indicated a statistically significant predominance sympathicotonia at rest and active orthostasis, indicating serious violations of adaptation in the examinees.
Subject(s)
Adaptation, Physiological , Heart Rate/physiology , Hepatitis C, Chronic/physiopathology , Liver Cirrhosis/physiopathology , Parasympathetic Nervous System/physiology , Sympathetic Nervous System/physiology , Case-Control Studies , Hepatitis C, Chronic/virology , Humans , Liver Cirrhosis/virologyABSTRACT
Sixty-two and 58 patients with hypo- and hypermotor biliary tract dysfunction (BTD), respectively, as well as 59 patients with chronic acalculous cholecystitis (CAC) and 63 with opisthorchiasis-complicated CAC were examined. A control group comprised 33 patients of the same sex and age. All the patients underwent fractional duodenal intubation, followed by clinical, biochemical, and serological bile studies. All the examinees were found to increased gallbladder bile lithogenicity, minor changes being observed in biliary tract dysfunction and more pronounced ones being in opisthorchiasis. A biochemical study of gallbladder bile, followed by its lithogenicity correction, is recommended in the treatment of different forms of BTD.
Subject(s)
Bile/metabolism , Biliary Tract Diseases/metabolism , Gallbladder/metabolism , Adult , Biliary Tract Diseases/pathology , Biliary Tract Diseases/therapy , Female , Gallbladder/pathology , Humans , Male , Middle AgedSubject(s)
Autonomic Nervous System Diseases/etiology , Biliary Dyskinesia/etiology , Cholecystitis/complications , Mood Disorders/etiology , Opisthorchiasis/complications , Adult , Anthelmintics/therapeutic use , Autonomic Nervous System Diseases/physiopathology , Biliary Dyskinesia/physiopathology , Cholecystitis/drug therapy , Chronic Disease , Gallbladder/physiopathology , Humans , Opisthorchiasis/drug therapy , Psychotropic Drugs/therapeutic useABSTRACT
A complex clinico-instrumental, laboratory and psychological examination of 122 patients with chronic non-calculous cholecystitis (CNCC), 63 of who had chronic opisthorchosis (CO), was conducted. The controls were 33 healthy individuals. Patients with CNCC and CO had hypomotoric dyskinesia, Oddi's sphincter dysfunction, higher levels of personal anxiety and depression more often than others.
Subject(s)
Anxiety/etiology , Cholecystitis/complications , Depression/etiology , Opisthorchiasis/complications , Adult , Anxiety/epidemiology , Anxiety/psychology , Cholecystitis/psychology , Chronic Disease , Depression/epidemiology , Depression/psychology , Humans , Incidence , Opisthorchiasis/psychology , Prognosis , Psychological TestsABSTRACT
GOAL OF THE STUDY: Complex study of psychovegetative disorders at hypermotor dysfunction of biliary ducts in young people and correction of these disorders with the help of grandaxin. MATERIAL AND METHODS OF STUDY: Thirty-five patients with hypermotor dysfunction (biliary dyskinesia). The control group comprised 33 patients of the same sex and age. The mental status was assessed with the use of BMQP (brief multifactorial questionnaire for personality examination), Spielberger, Eysenck and Heck-Hess tests. The cardiac rate mathematical analysis method by R.M. Bayevsky and Wein-Solovyova tables were used to study the vegetative nervous system function. Vegetative disorders were corrected with the help of grandaxin. STUDY RESULTS: The mental status of patients with biliary dyskinesia differed reliably from that in the control group. When the vegetative system was examined in the biliary dyskinesia group in the state of rest, the parasympathetic reaction was greatly increased at the load, being greater than in the control group. CONCLUSION: When biliary dyskinesia is treated, it is recommended to correct psychovegetative disorders with the help of an original drug named grandaxin.
Subject(s)
Antidepressive Agents/therapeutic use , Autonomic Nervous System/drug effects , Benzodiazepines/therapeutic use , Biliary Dyskinesia/drug therapy , Gallbladder/innervation , Adult , Antidepressive Agents/administration & dosage , Antidepressive Agents/pharmacology , Benzodiazepines/administration & dosage , Benzodiazepines/pharmacology , Biliary Dyskinesia/diagnosis , Biliary Dyskinesia/psychology , Gallbladder/drug effects , Heart Rate/drug effects , Humans , Treatment OutcomeABSTRACT
The aim was to study psychovegetative disorders in hypomotor and hypermotor forms of biliary diskinesia (BDK) in young patients. Psychological status and vegetative nervous function were studied in 62 patients with hypoBDK, 58 patients with hyperBDK and 33 control patients. According to AMPI, Spilberger's, Aizek's, Heck-Hess' tests, the psychological status of the patients from both groups was similar, while vegetative status in the hypoBDK group at rest and active orthostasis had a sympathetic trend. In hyperBDK group at rest sympathetic impacts enhanced, in stress these impacts intensified reaching higher values than in the control group. For the treatment of various forms of BDK, it is recommended to correct psychovegetative deviations with consideration of diskinesia forms.
