[Characteristics of the manifest and latent components of the hepatitis A epidemic process in cities of Russia]. / Kharakteristika manifestnogo i skrytogo komponentov épidemicheskogo protsessa gepatita A v gorodakh Rossii.

Seroepidemiological study of hepatitis A (HA) morbidity was carried out in three Russian cities, with different levels of HA morbidity. The study included the analysis of HA morbidity for 22 years, the determination of antibodies to HA virus (anti-HAV) in 2,958 healthy persons aged 0-12 months to 40 years and older. In one of the cities 7 isolates of HA virus were obtained from unrelated sources and the genotypes of the virus were determined. The study revealed that the frequency of seropositive cases among persons of different ages correlated with the level and prolonged dynamics of HA morbidity. According to the occurrence of anti-HAV, such cities as St. Petersburg, Rostov-on-Don and Yakutsk may be at present classified as territories, moderately endemic in HA. At the same time in the 90 s the epidemic situation in HA was more favorable in Rostov-on-Don than in two other cities. The suggestion was made that a high proportion of seropositive persons among the population of St. Perersburg was linked with an almost twofold rise in HA morbidity in 1993-1995 caused by genotype 1 of the virus. Seroepidemiological studies in HA during the period of a drop in morbidity acquire special importance in the surveillance and control system of this infection.

Experimental substantiation of allogenic tendon tissue transplantation.

Substantiation of transplantation of tendon allografts treated with a new solution showing both sterilizing and preservatory effects was provided in experiments on 84 dogs. The solution prepared on the basis of 0.1% formaldehyde with the addition of dimethyl sulphoxide, monomycin and prednisolone (FDMP) shows a high antimicrobial activity, preserves the structure of the tendons and their elasticity. In their duration, the processes of reconstruction of allografts preserved in FDMP are very similar to autotransplants. Clinical application of preserved tendons on repairing defects in 418 patients proved the method to be highly effective.

[Methods of sterilizing and preserving tendon transplants]. / Sposoby sterilizatsii sukhozhil'nykh transplantatov.

The authors describe three methods for making tendon transplants by using chemical sterilizing and preserving means having no unfavorable effect on their biological and plasty properties. The methods are simple, reliable and fairly suitable for a wide supply of clinical institutions with tendon transplants.