1.
Neurology
; 63(6): 1087-9, 2004 Sep 28.
Article
in English
| MEDLINE
| ID: mdl-15452305
ABSTRACT
The multidrug transporter P-glycoprotein is suspected of contributing to pharmacoresistance in temporal lobe epilepsy (TLE). To assess the role of functional variations in its coding gene (ABCB1) the authors genotyped 210 patients with TLE who were stratified according to their degree of drug resistance. They identified a common haplotype that when present in the homozygous state significantly increased the risk for pharmacoresistance.
Subject(s)
ATP Binding Cassette Transporter, Subfamily B, Member 1/physiology , Anticonvulsants/pharmacology , Drug Resistance, Multiple/genetics , Epilepsy, Temporal Lobe/genetics , ATP Binding Cassette Transporter, Subfamily B, Member 1/genetics , Adult , Alleles , Amino Acid Substitution , Anticonvulsants/therapeutic use , Austria , Epilepsy, Temporal Lobe/drug therapy , Exons/genetics , Female , Genotype , Haplotypes/genetics , Hippocampus/pathology , Humans , Magnetic Resonance Imaging , Male , Middle Aged , Mutation, Missense , Polymorphism, Genetic , Polymorphism, Single Nucleotide , Sclerosis
2.
Trustee
; 44(4): 16-7, 1991 Apr.
Article
in English
| MEDLINE
| ID: mdl-10110144
3.
Physiol Behav
; 12(2): 285-7, 1974 Feb.
Article
in English
| MEDLINE
| ID: mdl-4361193
Subject(s)
Avoidance Learning , Conditioning, Classical , Sleep Deprivation , Sleep, REM , Animals , Electroshock , Methods , Photic Stimulation , Psychology, Experimental/instrumentation , Rats , Research Design , Water
4.
JAMA
; 225(1): 49-51, 1973 Jul 02.
Article
in English
| MEDLINE
| ID: mdl-4145955
