Subject(s)
Abdominal Abscess , Drainage , Retroperitoneal Space , Suppuration/surgery , Surgical Procedures, Operative , Abdominal Abscess/complications , Abdominal Abscess/diagnostic imaging , Abdominal Abscess/physiopathology , Abdominal Abscess/surgery , Acinetobacter Infections/complications , Acinetobacter Infections/physiopathology , Acinetobacter Infections/surgery , Anti-Bacterial Agents/therapeutic use , Combined Modality Therapy , Humans , Male , Middle Aged , Postoperative Care/methods , Proctitis/complications , Proctitis/physiopathology , Proctitis/surgery , Radiography , Retroperitoneal Space/diagnostic imaging , Retroperitoneal Space/physiopathology , Retroperitoneal Space/surgery , Severity of Illness Index , Suppuration/complications , Suppuration/diagnosis , Suppuration/physiopathology , Surgical Procedures, Operative/adverse effects , Surgical Procedures, Operative/methods , Systemic Inflammatory Response Syndrome/etiology , Systemic Inflammatory Response Syndrome/physiopathology , Systemic Inflammatory Response Syndrome/therapy , Treatment OutcomeSubject(s)
Enterosorption , Intestinal Diseases/therapy , Postoperative Complications/therapy , Acute Disease , Bacteria/isolation & purification , Digestive System/microbiology , Humans , Intestinal Diseases/metabolism , Intestinal Diseases/microbiology , Intestinal Obstruction/surgery , Peritonitis/surgery , SyndromeABSTRACT
Infection of the biliferous system in patients with cholelithiasis was shown to be the most frequent when the levels of cholic acid in bile were low. Physiological concentrations of cholic and deoxycholic acids have antimicrobial activity against organisms not adapted to the presence in bile. Outer drainage of the bile ducts was accompanied by an increase in the levels of cholic acid when at the background of outer decompression bacteria were eliminated from the biliferous system. In vitro studies revealed a synergistic antibacterial effect of cholic and deoxycholic acid combinations with cefazolin.
Subject(s)
Bile/microbiology , Cholelithiasis/microbiology , Cholic Acids/metabolism , Deoxycholic Acid/metabolism , Enterobacteriaceae/isolation & purification , Pseudomonas aeruginosa/isolation & purification , Staphylococcus aureus/isolation & purification , Bile/metabolism , Cefazolin/pharmacology , Cholelithiasis/metabolism , Culture Media , Drug Synergism , Enterobacteriaceae/drug effects , Gentamicins/pharmacology , Humans , In Vitro Techniques , Pseudomonas aeruginosa/drug effects , Staphylococcus aureus/drug effectsSubject(s)
Anti-Bacterial Agents/therapeutic use , Cholecystitis/drug therapy , Acute Disease , Cholecystectomy , Cholecystitis/surgery , Choledochostomy , Cholelithiasis/drug therapy , Cholelithiasis/surgery , Combined Modality Therapy , Humans , Intraoperative Care , Postoperative Care , Postoperative Complications/prevention & control , PremedicationABSTRACT
Microscopic examination of native bile and smears stained with the Gram procedure rapidly provided information on the presence of bactericholia and the necessity of antibacterial therapy prior to closing of the postoperative wound in accordance with the drug spectrum. Determination of the phagocytic and bactericidal activity of the bile leukocytes was a significant adjuvant to routine microscopic examinations, whereas evaluation of the average cytochemical coefficient and phagocytosis intensity was an important factor in prognosis of postoperative pyoinflammatory complications. Gram-negative bacteria were the predominating causative agents of acute cholecystitis and cholangitis (89 per cent). Among them Escherichieae, Klebsielleae and P. aeruginosa were isolated most frequently (32.4, 31.1 and 16.4 per cent, respectively). Amikacin, tobramycin, sisomicin, gentamicin and cefotaxime showed the highest activity against the above pathogens. However, comparative analysis of the antibioticograms revealed differences in antibiotic sensitivity of separate bacterial species.
