ABSTRACT
The analysis of case history, clinical, laboratory and instrumental findings, objectively characterizing the patient's condition in two alternative groups (nonaspirin and aspirin bronchial asthma) enabled the authors to create a functional diagnostic model for aspirin bronchial asthma. The model-based computer program designed by the authors can perform early diagnosis of aspirin asthma outpatiently without any risk for the patients.
Subject(s)
Aspirin/adverse effects , Asthma/diagnosis , Computer Simulation , Diagnosis, Computer-Assisted/methods , Models, Biological , Adult , Asthma/chemically induced , Asthma/physiopathology , Diagnosis, Computer-Assisted/statistics & numerical data , Humans , SoftwareSubject(s)
Adaptation, Physiological , Health Status Indicators , Adult , Aging/blood , Arteriosclerosis/blood , Arteriosclerosis/epidemiology , Ecology , Humans , Lipids/blood , Male , Middle Aged , Occupational Exposure/adverse effects , Occupational Exposure/statistics & numerical data , Petroleum , Risk Factors , Russia/epidemiologyABSTRACT
Status metry was used to determine the portion of congenital developmental abnormalities (CDA) of obscure etiology (probably of mutation origin) among the total number of CDA in 3 cities of the Ukraine. The contribution of CDA determined by new mutations correlates with the reported data and corresponds with the level of atmospheric air pollution in the cities under study. Status metry made it also possible to define the tendencies and magnitude of the influence of factors involved in CDA formation. The conclusion is made about adequacy of the use of status metry for indirect estimation of the rate of the mutation process and its modification under the effect of environmental pollution.
Subject(s)
Abnormalities, Drug-Induced/epidemiology , Air Pollutants/adverse effects , Abnormalities, Drug-Induced/genetics , Female , Humans , Infant, Newborn , Male , Models, Statistical , Mutation , Occupational Exposure , Pregnancy , Ukraine/epidemiologySubject(s)
Antibody Formation/physiology , Blood Donors , Immunization , Adult , Humans , Middle Aged , PrognosisABSTRACT
A complex examination was made of 72 men--short-wave (3-30 MHz) radio equipment controllers. Two parallel control groups of 70 people all in all were examined. No regular changes in the dynamics of amplitude-frequency characteristics of electroencephalogram, associated with the length of service, were observed. The number of subjective complaints from people in contact with radiofrequencies increased with an increase in the length of service. The role of certain clinico-physiological parameters of the organism in the process of adaptation to electromagnetic radiation was quantitatively assessed with the use of status-metry technique; in particular, a decrease in the functional activity of the right hemisphere brain structures, aggravating with the length of service, was observed.
Subject(s)
Occupational Diseases/etiology , Radio Waves/adverse effects , Adult , Electrocardiography , Electroencephalography , Electromagnetic Fields , Humans , Male , Middle Aged , Occupational Diseases/diagnosis , Occupations , Time FactorsABSTRACT
Statusometry, a method of automated quantitative assessment of the state of composite multiparametrical objects, is proposed for the detection of genetic predisposition to myocardial infarction as an instrument of integral quantitative assessment of systemic immunogenetic status on the basis of HLA phenotype. The prognostic error does not exceed 15%. Large-scale application of the new method appears a promising approach to individualization and better efficiency of preventive cardiologic treatment.
Subject(s)
HLA Antigens/analysis , Myocardial Infarction/genetics , Humans , Male , Myocardial Infarction/immunology , Phenotype , PrognosisSubject(s)
Aging/physiology , Health Status , Health , Immune System/physiology , Metabolism , Adolescent , Adult , Aged , Female , Humans , Middle Aged , Reference ValuesABSTRACT
The method of mathematical theory of experiment was used to find optimum variants of the radioprotective complex APAETP + mexamine. The character of their pharmacological interaction, depending on their dose ratio, was determined. It is suggested that it is conditioned by the specific role of different mechanisms involved in the radioprotective effect.
Subject(s)
5-Methoxytryptamine/administration & dosage , Amifostine/administration & dosage , Organothiophosphorus Compounds/administration & dosage , Radiation Injuries, Experimental/prevention & control , Radiation-Protective Agents , Tryptamines/administration & dosage , Amifostine/metabolism , Animals , Dose-Response Relationship, Drug , Drug Combinations , Male , Mice , Tissue DistributionABSTRACT
A study was made of the possibility of using a mathematical theory of experiment in developing effective many-component radioprotective preparations. The preparations composed of cystamine or S-(omega-aminopropyl)-beta-aminoethyl thiophosphate, as the basis, and mexamine, ethyron and gutimine were used as an example to prove the adequacy of such an approach in solving the problems of optimization of composing the radioprotective complexes according to their efficiency and toxicity.
