1.
Bull Exp Biol Med
; 133(5): 518-20, 2002 May.
Article
in English
| MEDLINE
| ID: mdl-12420078
ABSTRACT
A new method for preclinical evaluation of safety of antiarrhythmic drugs is proposed. During chronic stress, class I antiarrhythmic preparations increased mortality of test animals. By contrast, class II-IV antiarrhythmic agents and antioxidants produced no significant effect on mortality of experimental mice. These data agree with published results of multicenter studies.
Subject(s)
Anti-Arrhythmia Agents/pharmacology , Clinical Trials as Topic/methods , Drug Evaluation, Preclinical/methods , Animals , Antioxidants/pharmacology , Mice , Multicenter Studies as Topic , Time Factors
2.
Biull Eksp Biol Med
; 129(1): 31-3, 2000 Jan.
Article
in Russian
| MEDLINE
| ID: mdl-10710622
