[Lipid peroxidation and blood serum peroxidase activity in diseases of the hepatobiliary system]. / Perekysne okyslennia lipidiv i peroksydazna aktyvnist' syrovatky krovi pry zakhvoriuvanniakh hepatobiliarnoï systemy.

Patients with hepatobiliary pathology showed an augmentation of peroxide oxidation of lipids (LP), its degree dependent upon the severity of the clinical course of the medical condition in question, being the highest in those patients with viral hepatitis, carcinoma of the head of pancreas, and portal cirrhosis of the liver. A parallel investigation into the blood serum peroxidase activity, the main indicator of the antioxidant activity, in the above patients, showed a noticeable decrease in PA activity. LP and blood serum PA measurements allow some judgement about the gravity of the course of hepatobiliary pathology and effectiveness of the therapy adopted.

[The cytochemical determination of alpha-glycerophosphate dehydrogenase and adenosine triphosphatase in the peripheral blood lymphocytes of patients with hepatobiliary system pathology]. / Tsytokhimichne vyznachennia al'fa-hlitserofosfatdehidrohenazy ta adenozyntryfosfatazy limfotsytiv peryferychnoï krovi u patsiientiv z patolohiieiu hepatobiliarnoï systemy.

In patients with pancreatic head cancer and virus hepatitis the lowest values of alpha glycerophosphate dehydrogenase and adenosine triphosphatase in the peripheric blood lymphocytes were determined. The dynamic study of these values in patients with pathology of liver and biliary ducts permits to estimate the disease severity course and equally with other clinico-laboratory data may have prognostic significance.

[The alpha-glycerolphosphate dehydrogenase and adenosinetriphosphatase activity of the peripheral blood lymphocytes in diabetics (a cytochemical determination)]. / Aktyvnist' al'fa-hlitserofosfatdehidrohenazy i adenozyntryfosfatazy limfotsytiv peryferychnoï krovi khvorykh na tsukrovyi diabet (tsytokhimichne vyznachennia).

Decrease in activity of alpha-GPDG and ATP-ase observed in peripheral lymphocytes of patients with diabetes mellitus correlated well severity of the disease. The lowest indices of enzymatic activity were registered in patients with grave diabetes complicated by angiopathies, foot gangrene, and purulent inflammatory processes. Compensation of carbohydrates metabolism and improvement of clinical picture were accompanied by the trend to normalization of enzymes' activity. Dynamic study of alpha-GPDG and ATP-ase in patients with diabetes mellitus allows to evaluate degree of hypoxia, comprehend the nature of compensation mechanisms and assess effectiveness of the treatment.

[The use of continuous plasmapheresis and extracorporeal laser irradiation of the blood in treating diabetic angiopathies of the lower extremities]. / Zastosuvannia bezperervnoho plazmaferezu i ekstrakorporal'noho lazernoho oprominennia krovi u likuvanni diabetychnoï anhiopatiï nyzhnikh kintsivok.

The plasmapheresis (PP) with the help of the PP-05 apparatus was applied in the treatment of 70 patients with the low extremities diabetic angiopathy. The optimal plasma exfusion dose is from 600 to 1100 ml. Under the PP influence the blood glucose level reduced proportionally to the excreted plasma quantity, the rheovasographic index on the low extremities increased from 0.41 +/- 0.15 to 0.64 +/- 0.6; the bloodflow velocity in the peripheral arteries of low extremities have got the 2.2-fold rise according to the dopplerography data. In comparison with a control group of patients the exarticulation conduction frequency decreased from 20 to 8, and extremities amputation--from 14 to 5.

[The prognostic significance of natural killers and dehydrogenases of the peripheral blood lymphocytes in patients with a suppurative inflammation]. / Prohnostychne znachennia pryrodnykh kileriv i dehidrohenza limfotsytiv peryferichnoï krovi u khvorykh z hniinym zapalenniam.

In patients with purulent inflammation foci of various location, reduction in the number of natural killers (NK) and in the activity of alpha-glycerophosphatedehydrogenase (alpha-GPDH) and adenosinetriphosphatase (ATP-ase) of lymphocytes was revealed. Maximum reduction in indices of NK, alpha-GPDH and ATP-ase was noted in patients with diffuse peritonitis, phlegmonous-gangrenous cholecystitis, destructive appendicitis. After treatment, the mentioned indices increased, but by the time of discharge of the patients from the hospital they were lower than the normal ones.

[The clinical significance of determining sulfhydryl groups and succinate dehydrogenase in the peripheral blood lymphocytes of patients with liver and biliary tract pathology]. / Klinichne znachennia vyznachennia sul'fhidryl'nykh hrup ta suktsynatdehidrohenazy limfotsytiv peryferychnoï krovi u khvorykh z patolohiieiu pechinky ta zhovnykh shliakhiv.

It was established that patients with hepatobiliary pathology showed a reduction of SH groups and activity of lymphocyte succinate dehydrogenase of the peripheral blood. The level of this reduction depended on the severity of the pathological process and was lowest in viral hepatitis and cancer of the head of the pancreas. A dynamic study of SH groups and SDG in these groups of patients makes it possible to evaluate disorders of oxidation, oxidation, severity of the disease; it is also of prognostic significance.

[The significance of determining the peripheral blood succinate dehydrogenase in the lymphocytes and large granule-containing lymphocytes in diseases of the hepatobiliary system]. / Znachenie opredeleniia suktsinatdegidrogenazy limfotsitov i bol'shikh granulosoderzhashchikh limfotsitov perifericheskoi krovi pri zabolevaniiakh gepatobiliarnoi sistemy.

In patients with carcinoma of the pancreas head and in patients with viral hepatitis a pronounced reduction of activity of lymphocyte succinic dehydrogenase was detected. The determination of large granular lymphocytes is considered to be a sufficiently informative test of the state of nonspecific immunity in patients with a pathology of the hepatobiliary system.

[The sulfhydryl groups and succinate dehydrogenase activity of the peripheral blood lymphocytes in diabetic patients]. / Sul'fhidryl'ni hrupy i aktyvnist' suktsynatdehidrohenazy limfotsytiv peryferychnoï krovi u khvorykh na tsukrovyi diabet.

The peripheral blood lymphocytes of 72 patients with insulin-dependent diabetes mellitus showed a reduction of the SH groups and succinate dehydrogenase (SDG) activity, their grade depending on the severity of the pathological process. A dynamic study of the SH-groups and SDG activity of lymphocytes enable to evaluate the severity of disturbance of the oxidation-reduction processes in patients with diabetes mellitus. These data have also a prognostic significance.

[Sulfhydryl groups and succinate dehydrogenase of blood lymphocytes in patients with inflammatory processes]. / Sul'fgidril'nye gruppy i suktsinatdegidrogenaza limfotsitov krovi u bol'nykh s vospalitel'nymi protsessami.

Patients with pyo-inflammatory processes were found to have a reduced SH-group content and SDH activity of peripheral blood lymphocytes. A clear dependence between the severity and extent of the pyo-inflammatory process and the SH-group and SDH values. Lymphocyte SDH is more sensitive than the SH-groups to the pyo-inflammatory process and responds by reduced activity. Study of SDH activity and SH-group content of lymphocytes in dynamics are sensitive tests for the severity of the pyo-inflammatory process, unspecific reactivity of the organism, and the efficacy of the applied treatment.

[The significance of the lymphocyte adherence inhibition test in patients with diffuse toxic goiter]. / Znachenie testa podavleniia prilipaniia limfotsitov u bol'nykh diffuznym toksicheskim zobom.

Patients with diffuse toxic goiter reveal an increased adhesive capacity of lymphocytes evidencing a reduction of lymphokine production by lymphocytes which would suppress adhesiveness. The degree of increase of adhesive properties of lymphocytes depended on the severity of the clinical picture of diffuse toxic goiter, being higher in those with a severe course. Results of the test of lymphocyte adhesion suppression reflect the state of cellular immunity, severity of the clinical course of diffuse toxic goiter and efficacy of treatment.

[The clinical significance of the sulfhydryl groups in the peripheral blood lymphocytes of patients with thyrotoxic goiter]. / Klinichne znachennia sul'fhidryl'nykh hrup limfotsytiv peryferiinoï krovi u khvorykh na tyreotoksychnyi zob.

A study of 42 patients with thyrotoxic goiter revealed a reduction of SH groups in the peripheral blood lymphocytes. The reduction depended on the severity of the pathological process. Changes of the SH groups are an informative criterion of the severity of the disease and treatment efficacy.

[Sulfhydryl group levels and the succinate dehydrogenase activity in peripheral blood lymphocytes in patients with cancer of the stomach]. / Vmist sul'fhidryl'nykh hrup ta aktyvnist' suktsynatdehidrohenazy limfotsytiv peryferiinoï krovi u khvorykh na rak shlunku.

In patients with gastric cancer, decrease in the level of SH-groups and activity of succinate dehydrogenase (SDH) of the peripheric blood lymphocytes which is indicative of the disturbance in oxidation-reduction processes was revealed. Degree of decrease in the indices depended on stage of the disease and severity of the course of a pathological process. SDH lymphocytic activity is the more sensitive test than content of SH-groups. The indices mentioned are used as an informative test for evaluation of the effectiveness of treatment.

[Study of immunologic reactivity of patients with cancer of the stomach based on the data of the adhesive capacity of lymphocytes]. / Izuchenie immunologicheskoi reaktivnosti u bol'nykh rakom zheludka po dannym opredeleniia adgezivnoi sposobnosti limfotsitov.

In patients with gastric cancer, the increase in adhesive lymphocytic capacity, as compared to a control, was revealed. It is indicative of the reduction in production of lymphokines, causing inhibition of adhesion. The highest value of the index was noted in IV stage gastric cancer. The results of study of the adhesive properties of the peripheric blood lymphocytes allow to judge about the state of cellular immunity, and in the complex with the other clinico-laboratory findings, are of a prognostic value.