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Eksp Klin Gastroenterol ; (7): 106-20, 2016.
Article in Russian | MEDLINE | ID: mdl-30284433

ABSTRACT

Probiotics for decades were leading in the arsenal of tools for correction of intestinal microbiocenosis. However, the response of representatives of intestinal microbiota to enteral intake of probiotics is variable, and in some individuals may be missing. Despite the fact that scientists still disagree on the necessity of forced settlement of normal microbiota at intestinal dysbiosis, large number of medicinal products, functional foods, dietary supplements, which efficiency is not always straightforward, is available for sale. The results of comparative experimental study of the effectiveness of 18 modern preparations for correction of intestinal microbiocenosis at antibiotic-associated dysbiosis in animals are presented. Conclusion is done on the need to evaluate efficacy and safety of tools developed for intestinal microbiota correction in animal experiments, followed by confirmation of clinical trials.


Subject(s)
Anti-Bacterial Agents/adverse effects , Dysbiosis , Gastrointestinal Microbiome/drug effects , Prebiotics/administration & dosage , Probiotics/pharmacology , Synbiotics/administration & dosage , Animals , Anti-Bacterial Agents/pharmacology , Drug Evaluation, Preclinical , Dysbiosis/chemically induced , Dysbiosis/microbiology , Dysbiosis/therapy , Humans , Mice
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