ABSTRACT
In patients with coronary heart disease oxidizability of lipids during Cu(2+)-induced oxidation of blood plasma inversely correlated with fibrinogen content. A positive correlation was found between the amount of lipid peroxidation products in the plasma from these patients and fibrinogen content. The increase in fibrinogen content was associated with high levels of total lipids and triglycerides and low concentration of high-density lipoprotein cholesterol. In vitro experiments demonstrated that fibrinogen reduces oxidizability of blood plasma. Our results suggest that the decrease in lipid oxidizability at high concentration of fibrinogen in patients with coronary heart disease is related to predominant oxidation of fibrinogen and its competition with plasma lipids during Cu(2+)-induced oxidation.
Subject(s)
Coronary Disease/metabolism , Fibrinogen/metabolism , Lipid Peroxidation/physiology , Coronary Disease/blood , Humans , Lipid Peroxides/blood , Lipid Peroxides/metabolism , Oxidative StressABSTRACT
Magnetic resonance spectroscopy revealed structural modifications of human plasma lipoproteins during peroxidation induced by copper sulfate in vitro. Decreased molecular mobility of fatty acid chains in lipoprotein lipids was demonstrated.
