[Evaluation of the degree of ischemia of the lower extremities in arteriosclerosis obliterans based on the levels of toxic metabolites in the blood]. / Otsenka glubiny ishemii nizhnikh konechnostei pri obliteriru- iushchem ateroskleroze arterial'nogo rusla po urovniu toksichnykh metabolitov krovi.

An attempt is made to elaborate biochemical criteria of the depth of ischemia in atherosclerotic lesions of the lower limb arterial channel, based on the degree of manifestation and character of the metabolic changes. The study revealed increased content of toxic metabolites--middle mass molecules (MMM), hydroperoxides, and circulating immune complexes (CIC) in the blood of patients. The content of MMM and hydroperoxides correlated with the degree of limb ischemia. Determination of MMM, hydroperoxides, and CIC may help in evaluating the severity of the pathological process and solving problems of preoperative management of patients from the standpoint of prescribing extracorporeal methods of detoxification.

[Concentration of acid-soluble metabolites--middle molecules in the blood of bronchial asthma patients]. / Soderzhanie kislotorastvorimykh metabolitov--molekul srednei massy v krovi bol'nykh bronkhial'noi astmoi.

The level of the derivatives of protein and lipid metabolism increases in the blood of patients with bronchial asthma (BA) and chronic asthmatic bronchitis (CAB), in particular that of peroxide radicals, the products of lipid peroxidation (LPO), the fraction of acid soluble metabolites--average mass molecules (AMM). The blood acquires unusual toxicity. The content of AMM in the blood of BA and CAB patients shows correlation with LPO and is in direct relation to severity of clinical symptoms. The removal of toxic products from the body by hemosorption promotes clinical remission and a decrease in AMM and LPO levels.