[Use of fish oil enriched with carotenoids isolated from sea cucumbers in the diet therapy of patients with hypertension and ischemic heart disease]. / Ispol'zovanie ryb'ego zhira, obogashchennogo karotinoidami iz morskogo ogurtsa, v dietoterapii bol'nykhg gipertonicheskoi bolezn'iu i ishemicheskoi bolezn'iu serdtsa.

Usage of antisclerotic diet with fish oil and carotinoides in patients with IND and high blood pressure resulted in positive dynamic of clinic manifestation, blood lipid, coagulogramms, antioxygen and immune status.

[Influence of bioactive dietary supplement--dietary unsaturated fats--on immune status of patients with myocardial ischemia and impaired glucose tolerance]. / Vliianie biologicheski aktivnoi dobavki k pishche--istochnika PNZhK-- na immunnyi status bol'nykh ishchemicheskoi bolezn'iu serdtsa s narushennoi tolerantnost'iu k uglevodam.

Immune status measured by the flow cytrometric analysis under the ischemic heart disease and IHD with impaired glucose tolerance has been found to be altered in B cells as well as in T lymphocytes in some cases. Having received the diet supplemented by PUFA "Eicolen", IHD patients present with the restored immune status. Patients with IHD and impaired glucose tolerance did not present with any significant modifications in immune status after PUFA "Eicolen" supplementation.

[Correction of mineral metabolism impairment with an allowance for seasonal fluctuations in patients with ischemic heart disease and hypertensive disease with overweight]. / Korrektsiia narusheniia mineral'nogo obmena s uchetom ego sezonnykh kolebanii u bol'nykh ishemicheskoi bolezn'iu serdtsa i gipertonicheskoi bolezn'iu s izbytochnoi massoi tela.

The influence of antiaterosclerotic diet with including some biologically active supplements (BAS), containing Zn, Mg, Na, K, Ca, vit C, E, B2, B6, beta-carotene, I was studied in 164 patients with ischemic heart disease and hypertension disease. BAS has been use with an allowance for seasonal fluctuations of microelements sufficiency. The usage of BAS "Lifepack" has priority in spring. The usage of biologically active supplements during 4 weeks in spring has promoted positive changes of clinical symptoms of diseases against a background of lowering increasing of K, Ca, Mg, Cu, Zn.

[Clinical-metabolic evaluation of the effectiveness of the olive oil use in patients with cardiovascular diseases]. / Kliniko-metabolicheskaia otsenka éffektivnosti primeneniia olivkovogo masla v dietoterapii bol'nykh s serdechno-sosudistymi zabolevaniiami.

Investigation of influence of diet with olive oil on clinical, metabolic and immune indices in patients with ischemic heart disease and hypertension was conducted. As a result of the diet modified by the lipid component positive effect on the course of the diseases and lipid spectrum of blood, pronounced action on some indices of cell immunity, intensity of processes of lipid peroxidation were observed.

[Dietetic canned food using ocean fish and plant components]. / Dieticheskie konservy na osnove okeanicheskikh ryb s fitodobavkami.

The results of the creating canned ground goods of a new kind are described in this article. The main character references of food value of hake and the canned ground foods based on it. It has been established that the new products of safety. Clinical tests have been showed the efficiency of including these canned goods in the menu of fat patients, also with heavy obesity. Dietetic canned ground foods on the base of oceanic fishes with plant additives.

[Effects of antiatherosclerosis diet including soy protein on the dynamics of clinical, biochemical and immunologic indicators in patients with ischemic heart disease and hypertension]. / Vliianie antiateroskleroticheskoi diety s vkliucheniem soevogo belka na dinamiku kliniko-biokhimicheskikh i immunologicheskikh pokazatelei u bol'nykh ishemicheskoi bolezn'iu serdtsa i gipertonicheskoi bolezn'iu.

Investigation of influence of diet with soy-protein on clinical and immune indices in patients with ischemic heart disease and hypertension was conducted. As a result of the diet modified by the protein component positive effect on the course of the diseases and lipid spectrum of blood, pronounced action on some indices of humoral immunity, intensity of processes of lipid peroxidation were observed.

[Juices in therapeutic-prophylactic nutrition]. / Soki v lechebno-profilakticheskom pitanii.

The main aspects of using juices with therapeutic and prophylactic purposes are demonstrated. Multifactorial influence of vegetable and fruit juices on the organism, primarily depends on their chemical composition. The necessity of their differentiated use basing not only nosological unity, but also on the degree of functional and metabolic disorders taking place in certain pathology is emphasized. Different juices are characterized in respect to the effect on different functional systems of the body. The new line in research is the ability of juices to change pharmacokinetics and pharmacodynamics of medicines given with juices. The importance of juices as a necessary element of therapeutic and healthy nutrition in case of their using in adequate amounts is emphasized.

[Clinical and metabolic effects of biological active food additives--phospholipids--in patients with cardiovascular diseases]. / Izuchenie kliniko-metabolicheskikh éffektov biologicheski aktivnoi dobavki k pishche--fosfolipidov--u bol'nykh serdechno-sosudistymi zabolevaniiami.

Uses of new phospholipid-containing food supplement 'Tonus' in patients with ischemic heart disease, hyperlipoproteinemia or hypertension during 4 weeks promoted positive changes clinical symptoms of diseases against a background of lowering of serum cholesterol, triglycerides and increasing of HDLP-cholesterol and improving liver function.

[The effect of vitamin- and beta-carotene-enriched products on the vitamin A allowance and the concentration of different carotenoids of the blood serum in victims of the accident at the Chernobyl Atomic Electric Power Station]. / Vliianie produktov, obogashchennykh vitaminani i beta-karotinom, na obespechennost' vitaminom A i kontsentratsiiu razlichnykh karotinoidov v syvorotke krovi lits, postradavshikh ot avarii na ChAES.

The results of clinical trials of efficiency of foods enriched by vitamins and beta-carotene in people suffered from Chernobyl's accident are presented. The level of beta-carotene in clinical diets was the same during trial. Daily consumption of enriched food supplying ingestion of 4-5 mg of beta-carotene increased the level of beta-carotene in serum by 2-4 times. The concentration of total carotenoides in serum was increased by 1.6 times practically at the expense of beta-carotene.

[Effects of diet containing polyunsaturated fatty acids omega-3 and different doses of vitamin E on the activity of lipid peroxidation in patients with hypertension]. / Izuchenie vliianiia diety, soderzhashchei polinenasyshchennye zhirnye kisloty omega-3 i razlichnye dozy vitamina E, na aktivnost' protsessov perekisnogo okisleniia lipidov u bol'nykh gipertonicheskoi bolezn'iu.

Change in lipid peroxidation processes (POL) have been studied in 32 patient with II degree hypertension disease after treatment by diet containing 20 g fish oil (eiconol) and 12.5 or 125 mg of vitamin E. The treatment with diet containing high level of PUFA did not cause increasing activity of POL. The treatment with diet AIM-125 containing high amount of vitamin E had not significant positive effect on clinical symptoms of hypertension and had no advantages in comparison with diet AIM-12.5 which ratio vitamin E:PUFA omega-3 was 2.5 mg:1mg.

[The antioxidant defense system in hypertension patients on a diet enriched with omega 3 polyunsaturated fatty acids and alpha-tocopherol]. / Issledovanie sistemy antiokislitel'noi zashchity u bol'nykh gipertonicheskoi bolezn'iu pri obogashchenii diety polinenasyshchennymi zhirnymi kislotami omega3 i alpha-tokoferolom.

A state of the anti-oxidation system in blood and the rate of lipid peroxidation were studied in patients with hypertension. High sensitivity of the anti-oxidation system enzymes to alterations in the diet fat composition was detected in the patients, nutrition of whom was evaluated in detail. Excessive doses of alpha-tocopherol, added to the diet enriched with omega 3-polyunsaturated fatty acids normalized lipid peroxidation and stabilized the enzyme activity involved in the anti-oxidation system. The integral parameter, proposed for evaluation of the anti-oxidation protection state and designated as "anti-oxidation index" involved estimation of catalase, superoxide dismutase, glutathione reductase and peroxidase activities as well as of content of malonic dialdehyde and diene conjugates in erythrocytes.

[Characteristics of the humoral immune system and lipid peroxidation processes in people living in territories contaminated with radionuclides]. / Kharakteristika sistemy gumoral'nogo immuniteta i protsessov perekisnogo okisleniia lipidov u lits, prozhivaiushchikh na territoriakh, zagriaznennykh radionuklidami.

Among 33 patients with Stage II hypertension, 25 persons were inhabitants of the Russian radionuclide-contaminated areas and 8 patients had no prior contacts with ionizing radiation (control). All the patients examined were maintained within 4 weeks on a diet, radioprotective effect of which was realized due to the elevated content of sulfur containing amino acids, antioxidants and complexes. In the patients who lived in the radionuclide-contaminated areas, a moderate activation of lipid peroxidation was detected simultaneously with marked alterations in the humoral component of the immunity system, which involved a considerable increase in the levels of IgG and complements C3 and C4. A decrease in content of malonic dialdehyde and diene conjugates as well as normalization of IgG and decrease in content of IgA, IgM and C3 were observed in blood plasma of the patients on diet. Supplementation of omega 3 polyunsaturated fatty acids (omega 3-PUFA), 5 g/day and alpha-tocopherol, 12.5 mg/day, to the diet elevated the serum concentrations of all lg classes, which suggests the presence of an immunomodulating effect of omega 3-PUFA. Moreover, the content of malonic dialdehyde was not increased in blood plasma if 3-PUFA was used. Hence, increased alpha-tocopherol levels should be used in the treatment of these patients with omega 3-PUFA (up to 5-7 mg per g PUFA) in order to stabilize lipid peroxidation.

[Effect of anti-arteriosclerosis diet, containing soya protein isolate and omega-3 polyunsaturated fatty acids on the activity of mononuclear and platelet lysosomal hydrolases in patients with hypertension and ischemic heart disease]. / Vliianie protivoateroskleroticheskoi diety, soderzhashchei izoliat soevogo belka i polinenasyshchennye zhirnye kisloty omega-3, na aktivnost lizosomalnykh gidrolaz mononuklearov i trombotsitov bolnykh ishemicheskoi bolezníu serdtsa i gipertonicheskoi bolezníu

In response to antiatherosclerosis dietotherapy containing 20 g of ichthyenic oil, coronary and hypertensive subjects showed lowered serum levels of cholesterol, triglycerides and atherogenic index, elevated HDLP cholesterol and corrected immunochemical shifts. SPI-containing diet resulted in changes of CIC IgM levels only. Shifts in the activity of mononuclear and platelet lysosomal hydrolases which occurred in the above patients due to relevant diets reflect higher sensitivity of this parameter in assessment of the dietotherapy effectiveness.

[The effect of a soy protein isolate and sources of polyunsaturated omega-3 fatty acids in an anti-atherosclerotic diet on the lipid spectrum of blood serum and immunological indicators in patients with ischemic heart disease and hypertension]. / Vliianie izoliata soevogo belka i istochnikov polinenasyshchennykh zhirnykh kislot omega3 v sostave protivoateroskleroticheskoi diety na lipidnyi spektr syvorotki krovi i immunologicheskie pokazateli u bol'nykh ishemicheskoi bolezn'iu serdtsa i gipertonicheskoi bolezn'iu.

Blood serum lipid spectra and immunologic spectra were studied in patients with ischemic heart disease and hypertension maintained on antiatherosclerotic diet containing either soy bean protein isolates or ichthyenic oil. The ichthyenic oil-containing diet decreased distinctly the level of cholesterol, triglycerides and the atherogenicity coefficient simultaneously with an increase of cholesterol content in high density lipoproteins in blood of 37 patients with these diseases. The diet with soy bean protein isolates exhibited less pronounced effects on lipid metabolism patterns in blood serum as compared with the ichthyenic oil-containing diet; however, the former diet contributed to normalization of the immunologic reactions in patients with ischemic heart disease and hypertension.

[The effect of dietotherapy on the clinico-immunological indices of rheumatoid arthritis patients]. / Vliianie dietoterapii na kliniko-immunologicheskie pokazateli bol'nykh revmatoidnym artritom.

The main requirements for the dietotherapy of rheumatoid arthritis (RA) patients have been formulated, and for the first time a pathogenetically balanced diet has been developed that produces antiinflammatory and immunocorrective effects. The effectiveness of the dietotherapy included into the combined treatment was studied in 41 patients with classic and proved RA. The authors have studied the influence of the dietotherapy on the clinical signs characterizing the activity of inflammation in the joints, and laboratory immunological parameters (IgG, IgM, IgA, IgD, the complement components: C1-inhibitor, C3, C4, C5, C9; haptoglobin, orrhozomucoid, transferrin, ceruloplasmin, alpha 1-antitrypsin, alpha 2-macroglobulin, prealbumin). The results of the study have shown that the dietotherapy is not only conducive to the improvement of the clinical picture of the disease, that permits diminishing the amount of nonsteroid antiinflammatory drugs used, but also produces a favourable effect on the RA patients' immunological state. It has been concluded that inclusion of the dietotherapy into the combined treatment of RA patients is advisable.

[Anti-atherosclerotic properties of some components of food (a clinico-experimental study)]. / Antiateroskleroticheskie svoistva nekotorykh komponentov pishchi (kliniko-éksperimental'noe issledovanie).

Platelet lysosomal proteinase and phospholipase activity, cholesterol content in the blood serum and circulating immune complexes, as well as blood serum atherogenic potential were studied with the use of human aortal intima atherosclerotic cell culture in patients with postinfarction cardiosclerosis (males aged from 45 to 62 years), 1-3 h before and 2-6 h after a single intake of one of the following products (50 g): sunflower oil, butter, cod fat, glucose, fructose, starch, dried milk protein, or 22 g of soybean protein isolate 500 U. The total data obtained have evidenced that the soybean protein isolate produces hypolipidemic and hypocholesterolemic effects, as well as possesses pronounced anti-atherosclerotic properties.

[Characteristics of water-electrolyte balance in patients with labile essential hypertension and various approaches to the optimal therapy with diuretics and low-sodium diet]. / Osobennosti vodno-élektrolitnogo obmena u bo'lnykh gipertonicheskoi bolez'niu s labi'lnoi gipertenziei i nekotorye podkhody k optimi- zatsii terapii diuretikami i dietami s nizkim soderzhaniem natriia.

A study of 56 males, aged 22 to 56 years, with uncomplicated essential hypertension, stages IB-IIA, where pretreatment examination was followed by repeat investigation after 4 or 5 weeks of treatment with diuretics or low-sodium diets with strict (less than 2 g), moderate (up to 3 g), or mild (4-4.5 g) restriction of sodium uptake, demonstrated a tendency to sodium retention with fluid redistribution from the interstitium to intravascular space in the presence of diuretic treatment. Where dietary sodium was reduced, extracellular sodium was increased owing to increased residual sodium, while total metabolic sodium dropped, and extracellular fluid increased owing to the increase in interstitial fluid. All three variants of the low-sodium diet produced changes in sodium metabolism, with a drop in systemic residual sodium and arterial blood pressure. It is proposed to use strict limitation of dietary sodium for a limited period of time, to be followed by a transition to mildly limited sodium uptake after arterial BP is brought down and stabilized.