1.
Antibiot Khimioter
; 50(5-6): 11-6, 2005.
Article
in Russian
| MEDLINE
| ID: mdl-16526603
ABSTRACT
In vitro selection of HIV-1(EVK) variants resistant to highly effective nucleoside reverse transcriptase inhibitors (NNRTIs), i.e. azidothymidine (AZT) and didanosine (ddI) was performed. In case of AZT resistant mutants, subcloning by limiting dilutions was used. The isolated AZT resistant mutants and subclones had a broad spectrum of phenotypic resistance (8, 25, 53, 80, 114, 160-fold). The ddI resistant mutant possessed 10-fold resistance. The AZT resistant mutants and subclones had a high level of cross-resistance to H-phosphonate of AZT (H-phAZT) and a moderate level of cross-resistance to d4T. Still, they were effectively inhibited by a new compound, i.e. phosphonate of d4T.
Subject(s)
Didanosine/pharmacology , HIV-1/drug effects , Reverse Transcriptase Inhibitors/pharmacology , Zidovudine/pharmacology , Drug Resistance, Viral , HIV-1/genetics , HIV-1/physiology , Mutation , Stavudine/pharmacology , Thymidine/analogs & derivatives , Thymidine/pharmacology
2.
Vestn Oftalmol
; 2: 57-60, 1974.
Article
in Russian
| MEDLINE
| ID: mdl-4831570
Subject(s)
Helium , Hyperopia/diagnosis , Lasers/instrumentation , Myopia/diagnosis , Neon , Adolescent , Child , Humans , Refraction, Ocular
3.
Med Tekh
; 5: 47-8, 1972.
Article
in Russian
| MEDLINE
| ID: mdl-4663465
4.
Mikrobiologiia
; 38(1): 22-8, 1969.
Article
in Russian
| MEDLINE
| ID: mdl-5345729
5.
Mikrobiologiia
; 35(6): 951-9, 1966.
Article
in Russian
| MEDLINE
| ID: mdl-6003013
