[Role of suppressor cells in neonatally induced tolerance to transplantable hepatoma 22A]. / Izuchenie roli supressornykh kletok pri neonatal'no indutsiruemoi tolerantnosti k transplantiruemoi gepatome 22A.

It was found that adoptive transfer of T lymphocytes from tumor-tolerant ice result in the enhancement of hepatoma 22a growth. This finding suggests an activation of suppressor cells. However, this activation is detectable only in the definite period during the immunologic tolerance induction.

[Role of adhesive lymphoid cell subpopulation in areactivity to hepatoma 22a]. / Izuchenie roli prilipaiushchei subpopuliatsii limfoidnykh kletok v areaktivnosti k gepatome 22a.

The role of adhesive fraction of T lymphocytes in nonreactivity of mice to hepatoma 22a was studied. It was shown that the removal of the adhesive fraction from the spleen suspension enriched with T lymphocytes promotes intensification of cell immunity in tumor-tolerant mice.

[Comparative study of the immune response of newborn and adult animals to the administration of tumor extracts]. / Sravitel'noe izuchenie immunologicheskogo otveta na vvedenie ékstrakta opukholi novorozhdennym i vzroslym zhivotnym

Immunological reactivity to hepatoma 22a was studied in newborn and adult mice pretreated with tumour antigens. Treatment of newborn mice enhanced the growth rate of hepatoma 22a. Analogous treatment of adult mice resulted in the immunization effect. Evidently this difference was connected with a possible change of immunological reactivity to the tumour in newborn mice. This is supported by the results of cell dynamics--a mediated immunity assessed by the macrophage migration inhibition test. Splenic cells of the pretreated adult mice possessed the capacity to depress the macrophage migration more intensively in comparison with those of the pretreated newborn mice.