1.
Clin Pharmacol Ther
; 94(3): 376-82, 2013 Sep.
Article
in English
| MEDLINE
| ID: mdl-23670120
ABSTRACT
From 2010 to 2012, nine systematic reviews reported highly variable conclusions regarding the association between carriage of a cytochrome P450 2C19 loss-of-function allele and the risk of adverse cardiovascular (CV) events in individuals using clopidogrel. Possible contributors to the variable findings include differences in patient populations, CV end points, and statistical models utilized by the systematic reviews, as well as unexplained heterogeneity, inconsistent/incomplete reporting, and risk of publication bias with respect to the primary studies.
Subject(s)
Aryl Hydrocarbon Hydroxylases/genetics , Meta-Analysis as Topic , Platelet Aggregation Inhibitors/adverse effects , Review Literature as Topic , Ticlopidine/analogs & derivatives , Cardiovascular Diseases/chemically induced , Clinical Trials as Topic/standards , Clopidogrel , Cytochrome P-450 CYP2C19 , Endpoint Determination , Genotype , Humans , Models, Statistical , Patient Selection , Platelet Aggregation Inhibitors/pharmacokinetics , Publication Bias , Research Design/standards , Ticlopidine/adverse effects , Ticlopidine/pharmacokinetics
2.
Diabetes Obes Metab
; 14(7): 670; author reply 671-2, 2012 Jul.
Article
in English
| MEDLINE
| ID: mdl-22651136