ABSTRACT
Resolution of racemic tiaprofenic acid (TA) has been performed using immobilized human serum albumin as the stationary phase. The eluent was phosphate buffer-acetonitrile-n-octanoic acid (90:10:0.015, v/v). Detection was achieved at 305 nm. The pharmacokinetics of the enantiomers were studied following oral administration into humans and after subcutaneous injection in rats. Plasma concentrations of (+)-TA were much greater than those of (-)-TA. For the rat, the pharmacokinetic parameters between (-)-TA and (+)-TA were all statistically different (p < 0.005).
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/analysis , Propionates/analysis , Administration, Oral , Animals , Anti-Inflammatory Agents, Non-Steroidal/administration & dosage , Anti-Inflammatory Agents, Non-Steroidal/pharmacokinetics , Chromatography, High Pressure Liquid , Dansyl Compounds , Humans , Hydrogen-Ion Concentration , Indicators and Reagents , Injections, Subcutaneous , Male , Propionates/administration & dosage , Propionates/pharmacokinetics , Protein Conformation , Rats , Rats, Wistar , Sarcosine/analysis , Serum Albumin , Silicon Dioxide , Spectrophotometry, Ultraviolet , StereoisomerismSubject(s)
Anti-Inflammatory Agents, Non-Steroidal/pharmacology , Arthritis, Rheumatoid/drug therapy , Osteoarthritis/drug therapy , Propionates/pharmacology , Adult , Animals , Cartilage, Articular/drug effects , Digestive System/drug effects , Dogs , Drug Evaluation , Drug Evaluation, Preclinical , Drug Tolerance , Female , Humans , Kinetics , Male , Mice , Pain, Postoperative/drug therapy , Propionates/adverse effects , Propionates/metabolism , Propionates/therapeutic use , Prostaglandins/biosynthesis , Rats , Synovial Fluid/metabolismABSTRACT
CDP Choline, a metabolic precursor of phospholipids, has been tested against placebo in a controlled randomized double blind study concerning 60 cases of severe head injuries (wide-spread cerebral contusions and/or severe concussion). In the treated group, a shortening of the comatose period and an acceleration of neurological deficits recovery have been observed. These results are tentatively attributed to an effect of the drug against brain edema, already documented on experimental models.
Subject(s)
Brain Injuries/complications , Choline/analogs & derivatives , Coma/drug therapy , Cytidine Diphosphate Choline/therapeutic use , Adult , Aged , Clinical Trials as Topic , Coma/etiology , Double-Blind Method , Female , Humans , Male , Middle Aged , Random Allocation , Time FactorsSubject(s)
Retinal Diseases , Retinal Vessels/injuries , Adult , Cytidine Diphosphate Choline/therapeutic use , Edema/diagnosis , Edema/drug therapy , Fluorescein Angiography , Humans , Male , Retinal Diseases/diagnosis , Retinal Diseases/drug therapy , Retinal Hemorrhage/diagnosis , Retinal Hemorrhage/drug therapy , SyndromeABSTRACT
Over the past few years considerable amount of clinical syndromes describing brain stem levels of lesion were reported. This work was undertaken to establish, if possible, a simplification of criterions of axial lesions in head injuries. 125 patients with severe head injuries were strictly selected. Statistical analysis of careful examination of clinical pattern was performed and correlated, when possible, with anatomical lesions. Only four homogeneous groups were isolated:--group I represents the cortico-sub-cortical level,--group II représents the diencéphalie level,--group III represents the upper brain stem level with two subdivisions dependent upon the mechanism of herniation : central or uncus,--group IV represents the lower brain stem level.
