1.
Pediatr Blood Cancer
; 49(5): 763, 2007 Oct 15.
Article
in English
| MEDLINE
| ID: mdl-17120239
Subject(s)
Lymphoma, T-Cell/diagnosis , Lymphoma, T-Cell/therapy , Receptors, Antigen, T-Cell, gamma-delta , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Child , Disease Management , Fatal Outcome , Humans , Leukemia, T-Cell/diagnosis , Leukemia, T-Cell/therapy , Liver Neoplasms/diagnosis , Liver Neoplasms/therapy , Male , Splenic Neoplasms/diagnosis , Splenic Neoplasms/therapy
2.
Pediatr Blood Cancer
; 42(3): 278-80, 2004 Mar.
Article
in English
| MEDLINE
| ID: mdl-14752867
ABSTRACT
Detection of Philadelphia chromosome (Ph) in childhood T-lineage acute lymphoproliferative disorders is a rare event. Additional cytogenetic abnormalities are particularly uncommon in ALL. We here report two cases with T lineage acute lymphoproliferative disorders (T-ALL and T-NHL) presenting with both cytogenetic alterations and BCR-ABL fusion transcripts, associated with an aggressive presentation and a poor outcome. We point out firstly on the cytogenetic aberrations, supporting the hypothesis of multi-lineage involvement of ALL expressing Ph chromosome; secondly, on the persistence of T-cell leukemic clone detected by minimal residual disease (MRD) analysis, despite of the early disappearance of BCR-ABL fusion transcript.