ABSTRACT
The authors studied the cytotoxic function, activity of NAD- and NADP-diaphorases in the peripheral blood lymphocytes in 57 patients with B-cellular variant of chronic lympholeukoses and found a significant reduction of the natural killer activity of lymphocytes, increased activity of NADP-diaphorase. Reduction of natural killer activity in patients with B-cell variant of chronic lympholeukoses did not depend on the activity of membrane diaphorases in peripheral blood lymphocytes.
Subject(s)
Dihydrolipoamide Dehydrogenase/blood , Leukemia, Lymphocytic, Chronic, B-Cell/enzymology , Lymphocytes/enzymology , NADPH Dehydrogenase/blood , Adult , Aged , Cytotoxicity Tests, Immunologic , Female , Humans , Killer Cells, Natural/immunology , Leukemia, Lymphocytic, Chronic, B-Cell/immunology , Leukocyte Count , Male , Middle AgedABSTRACT
The authors studied the effect of toxic doses of thyroxin on the content of vitamins C and B1 in different tissues of rats. On the 15-th day after administration of thyroxin one could observe a reduction of thiamin in the tissues of the animals. These changes were most pronounced in the liver. The content of vitamin in the tissues also showed a reduction. These changes in the content of the ascorbic acid occurred after prolonged administration of thyroxin.