[Specific features of the motor function of the digestive organs in persons with different degree of resistance to motion sickness]. / Nekotorye osobennosti motornoi funktsii organov pishchevareniia u lits s razlichnoi stepen'iu rezistentnosti k bolezni dvizheniia.

The effect of three exposures to Coriolis acceleration on the frequency and amplitude of fasting stomach contractions was investigated in 6 resistant and 16 susceptible to motion sickness test subjects. After tests all of them underwent gastroduodenoscopy and 4 subjects from each group were subjected to echography to measure gall bladder contractility in response to glucose-milk loads. After tests the motor activity of the stomach increased slightly in resistant subjects due to an increase of the amplitude and a slight decrease of biopotential frequency. During gastroscopy antral and pyloric sphincters were closed. In the stomach there was an insignificant amount of contents without gall. In the susceptible group, the motor activity was, on the contrary, inhibited due to a significant decline of the wave amplitude and frequency (by 40% and 11%, respectively). In the stomach, one or both sphincters were widely open; it also contained a large amount of gastric juice and gall. In 36% of susceptible and 17% resistant subjects, diaphragmatic hernia (at the esophageal opening) was found. Ultrasonic examination of the gall bladder showed that susceptible subjects developed its faster and stronger contraction when compared to resistant subject in response to glucose-milk loading. This pointed to a more prolonged duration of the gall excretion phase. Reactive changes of the gastroduodenal zone in response to motion tests facilitated duodenal-gastric reflux and major gastrointestinal symptoms of motion sickness.

[Results of examining the population in a region with high morbidity for oral mucosal cancer: precancerous changes]. / Rezul'taty obsledovaniia naseleniia v regione s vysokoi zabolevaemost'iu rakom slizistoi obolochki rta: predrakovye izmeneniia.

Interviewing and examination of a population characterized by a high level of morbidity of oral cavity cancer, supposedly induced by the use of nas, established a high incidence of leukoplakia and preleukoplakia at this site which are identified as precancerous lesions. The highest relative risk of oral cavity leukoplakia was found in persons who both chew nas and smoke tobacco (12.4). Relative risk of leukoplakia is also elevated in those who either chew nas (5.6) or smoke cigarettes (7.7). This risk increases in step with the quantity of nas consumed per day as well as the number of cigarettes. The scrapings obtained from the oral cavity mucosa of nas chewers and cigarette smokers were shown to contain relatively higher levels of micronuclear cells. The results of this and previous investigations suggest that tests for the frequency of micronuclear cell occurrence may prove instrumental in identifying the early signs of carcinogenesis as well as in evaluating the efficacy of prophylactic measures.

[Radionuclide and thermographic diagnosis of head and neck neoplasms]. / Radionuklidnaia i termograficheskaia diagnostika novoobrazovanii golovy i shei.

Radionuclide and thermographic studies using 67Ga-citrate and 111In-bleomycin were performed in 129 patients with laryngeal cancer, chemodectoma of the neck, retinoblastoma, rhabdomyosarcoma of the orbital and facial soft tissues and cancer of the tongue. Elevated amounts of the radiopharmaceutical drug were found in patients with tumors. In thermographic studies higher thermogenic activity corresponding to the tumor was noted. Radionuclide thermographic studies extend diagnostic opportunities for head and neck tumors.

[Reaction to decreased circulating blood volume in persons subject and resistant to motion sickness (airsickness)]. / Reaktsiia na umen'shenie ob"ema tsirkuliruiushchei krovi u liudei, podverzhennykh i rezistentnykh k bolezni dvizheniia (ukachivaniiu).

The study of 54 healthy male test subjects demonstrated significantly different responses of motion sickness susceptible and resistant people to 10-minute occlusion of their femoral veins. The changes in limb rheograms, as well as heart rate and stroke volume indicated that in motion sickness susceptible subjects the circulating blood volume in the upper body decreased, whereas in motion sickness resistant subjects it remained unaltered or increased in response to the occlusion.

[Current concepts concerning the genesis of vestibulo-vegetative disorders in weightlessness]. / Sovremennye predstavleniia o geneze vestibulovegetativnykh rasstroistv v nevesomosti.

The up-to-date hypotheses of the genesis of vestibulo-vegetative disorders in weightlessness are taken under critical analysis. Preference is given to the concept which attaches greatest importance to the changes in stereotyped interactions of analyzers responsible for space perception. It is, however, emphasized that neither hypothesis can account for all the phenomena seen in crewmembers in orbital flight. It is, therefore, indicated that mechanisms of vestibulo-vegetative disorders need further study. It is believed that the most promising line of research is to study the role of endogenous factors determining individual variations of motion sickness susceptibility.

[Reaction to physical load in persons with a varying vestibular-autonomic resistance]. / Reaktsiia na fizicheskuiu nagruzku u liudei s razlichnoi vestibulo-vegetativnoi ustoichivost'iu.

The level of vestibular stability (tolerance to the double rotation test according to I. I. Bryanov) was compared with the pattern of changes in the heart rate and arterial pressure during exercise tests (20 squatting per 30 sec). The test subjects were 136 healthy male volunteers--representatives of different professions, aged 21--40. The subjects with high vestibular stability showed greater changes in heart rate (+29%) and a relatively stable diastolic pressure. The subjects with low vestibular stability displayed, on the contrary, greater changes in the diastolic (-9%) and pulse (+71%) pressure and a relatively low increase in heart rate. The time of recovery of the pressure level was significantly longer in the susceptible people. The possibility of predicting vestibular tolerance on the basis of responses to exercise tests was explored. Mathematical formulas of the theory of image recognition were used to develop a rule that makes it possible to identify 84.4% subjects with low vestibular stability in a given group.

[Effect of the orientation of the head in the gravitational field on the intensity of caloric nystagmus]. / Vliianie orientatsii golovy v gravitatsionnom pole na intensivnost' kaloricheskogo nistagma.

The relationship between the intensity of the vertical and horizontal caloric nystagmus and the head orientation in the gravity field was studied experimentally. The positions in which the nystagmus reached the highest intensity were identified. The experimental results showed that during caloric stimulation the major contribution to the excitation of semi-circular canals was made by the convective flow of the endolymph which was dependent on the head orientation relative to the acceleration vector. The caloric tests can induce stimulation of vertical semi-circular canals which is comparable to that of horizontal canals in its strength.

[Cardiovascular reactions in orthostatic tests and human resistence to vestibular stimuli]. / Serdechno-sosudistye reaktsii pri ortostaticheskikh probakh i rezistentnost' cheloveka k vestibuliarnym razdrazhiteliam.

The paper discusses the relationship between the vestibular stability of man and his cardiovascular regulation that develops during the recumbent-to-upright change of the body position. It describes specific parameters typical of the intermediate processes of the cardiovascular system that are prognostically important for the evaluation of the vestibular stability. The paper gives equations of multiple regression helping to predict the level of vestibular resistance with respect to the pattern of intermediate processes of the cardiovascular system during orthostatic tests.