ABSTRACT
The paper gives the results of using ozeltamivir in patients with influenza during the epidemic upsurge of morbidity in Russia in the 2006-2007 season. Comparative analysis of nucteotide sequences of viral strains isolated from the patients taking ozeltamivir revealed no marker mutations determining the resistance to this chemical.
Subject(s)
Antiviral Agents/therapeutic use , Influenza A Virus, H1N1 Subtype , Influenza A Virus, H3N2 Subtype , Influenza, Human/drug therapy , Oseltamivir/therapeutic use , Adolescent , Adult , Antiviral Agents/administration & dosage , Capsules , Cytopathogenic Effect, Viral/drug effects , Drug Administration Schedule , Drug Resistance, Viral/genetics , Female , Humans , Influenza A Virus, H1N1 Subtype/drug effects , Influenza A Virus, H1N1 Subtype/genetics , Influenza A Virus, H1N1 Subtype/isolation & purification , Influenza A Virus, H3N2 Subtype/drug effects , Influenza A Virus, H3N2 Subtype/genetics , Influenza A Virus, H3N2 Subtype/isolation & purification , Influenza, Human/epidemiology , Influenza, Human/virology , Male , Middle Aged , Moscow/epidemiology , Mutation , Oseltamivir/administration & dosage , Treatment OutcomeABSTRACT
The interferon response of leukocytes (IRL) alpha and gamma as well as the functional activity of natural killers (NK) were studied in patients with the verified diagnosis of acute viral hepatitis B (AVH-B) treated with leukinferon (a preparation of natural interferon-alpha and cytokines) and reaferon (recombinant alpha 2 interferon). The effect of therapy with LF and RF in patients with AVH-B manifested by an increase in the functional activity of NK up to complete normalization after termination of the course of therapy. In the group of patients treated with LF as a result of therapy IRL-alpha increased by the end of the treatment and in the convalescence period. The observed activation of NK and the IF-alpha system under the effect of IF preparations in patients with AVH-B correlated with enhanced elimination of HBsAg.
