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J Nat Prod ; 73(8): 1434-7, 2010 Aug 27.
Article in English | MEDLINE | ID: mdl-20684540

ABSTRACT

Three new aromatic epsilon-lactones, aggregatins A (1), B (2), and C (3), a new naphthoquinone derivative, aggregatin D (4), and three known anthraquinones, 2-methylanthraquinone, 7-methoxy-2-methylanthraquinone, and 7-hydroxy-2-methylanthraquinone, were isolated from the tubers of Sinningia aggregata (Gesneriaceae). Compounds 1 and 4 and the anthraquinones showed marginal antimicrobial activity.


Subject(s)
Anthraquinones/isolation & purification , Anti-Infective Agents/isolation & purification , Lactones/isolation & purification , Magnoliopsida/chemistry , Naphthoquinones/isolation & purification , Anthraquinones/chemistry , Anthraquinones/pharmacology , Anti-Infective Agents/chemistry , Anti-Infective Agents/pharmacology , Brazil , Escherichia coli/drug effects , Lactones/chemistry , Lactones/pharmacology , Microbial Sensitivity Tests , Molecular Structure , Naphthoquinones/chemistry , Naphthoquinones/pharmacology , Nuclear Magnetic Resonance, Biomolecular , Pseudomonas aeruginosa/drug effects , Staphylococcus/drug effects , Yeasts/drug effects
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