ABSTRACT
Kept under medical surveillance were 120 patients with duodenal ulcer running an uncomplicated course. All patients and 30 healthy donors were studied for the status of the immunity T-system by spontaneous E-rosette formation (E-RFC) and availability of theophylline-resistant (TPP-RFC) and theophylline-sensitive (TPS-RFC) lymphocytes. With B-system being studied by FAC-rosette formation. All patients with duodenal ulcer displayed a decline in the content of E-RFC, TFP-RFC, TFS-RFC as compared to the indices in controls. Inclusion into the combined therapy of thymalin and dalargin was noted to be associated with a positive dynamics in the rise of T-lymphocytes, their subpopulations to the level in controls, percentage of TFS-RFC. Indices for TFS-RFC did not differ from control ones either before or after the treatment.
Subject(s)
Adjuvants, Immunologic/therapeutic use , B-Lymphocyte Subsets/immunology , Duodenal Ulcer/drug therapy , Duodenal Ulcer/immunology , Enkephalin, Leucine-2-Alanine/analogs & derivatives , T-Lymphocyte Subsets/immunology , Thymus Hormones/therapeutic use , Adolescent , Adult , Aged , B-Lymphocyte Subsets/drug effects , Chronic Disease , Drug Evaluation , Enkephalin, Leucine-2-Alanine/therapeutic use , Female , Humans , Male , Middle Aged , T-Lymphocyte Subsets/drug effectsABSTRACT
A peptide was obtained at our chair, from the mucous membrane of the stomach of the pig, using a method of acid extraction. The above peptide belongs to the group of cytomedines and is conventionally called "mucozaline". As many as 80 Wistar male rats were used in comparative evaluation of thymaline, dallargine and "mucozaline" for their effect on the course of duodenal ulcer in the rat. The results obtained showed that regulatory peptides play an important part in protection of the gastric and duodenal mucosa against the damaging factors. Of the above agents, it is "mucozaline" that has the greatest protective action, with dallargine and thymaline following it in the declining order.
