ABSTRACT
Lipid peroxidation as well as effects of various interferons (native, from fibroblasts of new born and adult animals) on the peroxidation were studied in blood plasma, erythrocytes, liver and kidney tissues of mice with viral infection. These interferons, simultaneously with antiviral action, exhibited the positive effect on lipid peroxidation, while the interferon from fibroblasts of newborns produced the side reactions. Simultaneous use of the interferon and alpha-tocopherol removed these side reactions.
Subject(s)
Interferons/pharmacology , Lipid Peroxidation/drug effects , Orthomyxoviridae Infections/metabolism , Vitamin E/pharmacology , Animals , Influenza A virus , Malondialdehyde/blood , Mice , Orthomyxoviridae Infections/therapyABSTRACT
A relationship between the level of interferon production, intensity of lipid peroxidation, the activity of proteolytic enzymes, and the age of the blood serum donor was established on a model of peritoneal exudate cells from mice of different ages. Trypsin was found to inhibit interferon production levels in the same way as did the serum of newborn mice. Introduction of protease inhibitor increased interferon production considerably. Unlike that of mature animals, the blood serum of newborn mice had prooxidant properties.
