Subject(s)
Arrhythmias, Cardiac/physiopathology , Free Radical Scavengers/pharmacology , Hydrazines/pharmacology , Myocardial Reperfusion Injury/complications , Nitric Oxide Donors/pharmacology , Superoxide Dismutase/pharmacology , Animals , Arrhythmias, Cardiac/etiology , Arrhythmias, Cardiac/prevention & control , Drug Synergism , Female , Male , Nitrogen Oxides , RatsABSTRACT
Amino derivatives of ortho-benzoquinone (OBQ) were demonstrated to have a protective action in acute toxic hemic hypoxia induced by sodium nitrite given to laboratory animals. This action of OBQ was due to its capacity to activate the recovery of blood oxygen transport function by accelerating the restoration of methemoglobin and determined by their electron-acceptor properties, lipophilicity and NADP-dependent methemoglobin reductase affinity.
Subject(s)
Benzoquinones/therapeutic use , Hypoxia/drug therapy , Animals , Dose-Response Relationship, Drug , Drug Evaluation, Preclinical , Hypoxia/chemically induced , Methylene Blue/therapeutic use , Mice , Rabbits , Sodium Nitrite , Structure-Activity Relationship , Time FactorsABSTRACT
Complex of vitamins E and C showed the most effective antinecrotic action in rats with simulated myocardial infarction in series of antioxidants studied: ascorbate, alpha-tocopherol, quercetine, derivatives of o-benzoquinone OBQ2 and OBQ3. Stabilization of lipid peroxidation in cardiomyocytes, increase in biomembranes stability and absence of distinct alterations in the antioxidative enzymatic system were found in rats with ischemia and myocardial infarction after treatment with the complex. Protective effect of the vitamins E and C complex was realised via antiradical mechanism.
