ABSTRACT
Parkinsonism is a rare feature of immunological diseases. We describe a 67-year-old man with Caplan's syndrome (CS) and parkinsonism. CS is an immunologic disease characterised by the presence of rheumatoid arthritis associated with a specific form of pneumoconiosis. Parkinsonism as a manifestation of involvement of the central nervous system in this condition has never been reported. Following immunosuppressive treatment both the CS and the parkinsonian signs and symptoms showed a marked improvement. The role of immune mechanisms in these parkinsonian syndromes is discussed.
Subject(s)
Brain/pathology , Brain/physiopathology , Caplan Syndrome/complications , Caplan Syndrome/immunology , Encephalitis/immunology , Parkinson Disease/immunology , Aged , Anti-Inflammatory Agents/therapeutic use , Atrophy/diagnosis , Atrophy/immunology , Atrophy/physiopathology , Brain/immunology , Caplan Syndrome/drug therapy , Encephalitis/drug therapy , Encephalitis/physiopathology , Humans , Immunosuppressive Agents/therapeutic use , Lung/immunology , Lung/pathology , Lung/physiopathology , Magnetic Resonance Imaging , Male , Parkinson Disease/physiopathology , Parkinson Disease/therapy , Silicosis/complications , Treatment OutcomeABSTRACT
One hundred seventy-two term pregnant women with medical or obstetric conditions requiring induction of labor were treated with intracervical administration of 0.5 mg prostaglandin E2 in tylose gel. Multiple administrations were necessary in 42 cases (24.4%), two administrations in 31 cases (18.0%) and three administrations in 11 cases (6.4%). Intracervical administration of PGE2 tylose gel (0.5 mg dose) is useful to prime the cervix, induce labor, and significantly modify Bishop score.
