ABSTRACT
BACKGROUND AND AIMS: The long-term health effects of the use of electronic cigarettes (ECs) in patients with chronic obstructive pulmonary disease (COPD) are largely unexplored. We present findings from a 5-year prospective assessment of respiratory parameters in a cohort of COPD patients who substantially reduced conventional smoking or achieved abstinence by switching to ECs. METHODS: Patients were evaluated prospectively for their measurements of respiratory exacerbations, spirometric indices, quality of life using the COPD assessment tool (CAT), 6-min walk distance (6MWD), as well as conventional cigarette consumption. Baseline measurements prior to switching to EC use were compared with follow-up visits at 12-, 24-, 48- and 60-months. Age- and sex-matched COPD patients reporting to be regular smokers (not using ECs) were the reference group for the analysis. RESULTS: Complete data were available from 39 patients. Those in the EC user group achieved a marked decline in cigarette smoking or abstinence. COPD EC users had a significant diminution in COPD exacerbations; with the mean (±SD) exacerbation rate falling from 2.3 (±0.9) at baseline to 1.1 (±1.0) at 5 years (p < 0.001), whereas no significant changes were observed in the control group.Significant and constant improvements in lung function, CAT scores and 6MWD were reported in the EC user group over the 5-year observation period compared with the reference group (p < 0.05). CONCLUSION: The present study suggests that EC use may ameliorate objective and subjective COPD outcomes, and that the benefits gained appear to persist long term. EC use for abstinence and smoking reduction may ameliorate some of the harm resulting from tobacco smoking in COPD patients.
ABSTRACT
Tumor necrosis factor (TNF)-alpha is a proinflammatory cytokine. Blocking TNF-alpha has been demonstrated to be effective in various diseases, including both rheumatoid and psoriatic arthritis. There is evidence to show that levels of TNF-alpha are elevated in patients with severe asthma. TNF-alpha is involved in the initiation and perpetuation of the inflammatory process, epithelial damage and remodeling, and mucin hypersecretion. Furthermore, TNF-alpha polymorphism has also been reported in the asthmatic population. Based on the necessity for alternative treatments for asthmatics with severe disease and those who are particularly resistant to conventional asthma therapy, it has been shown that molecules targeted at blocking the effects of TNF-alpha probably constitute a considerable advance in the management of these difficult patients. This review focuses on the evidence of TNF-alpha axis upregulation in severe corticosteroid-refractory asthma, as well as the role of TNF-alpha inhibition and the adverse effects of treatment.
