ABSTRACT
Immunocorrective and detoxication treatment by plasma perfusion through fragments of alloplacental tissue (group 1), fragments of xenosplenic tissue (group 2) and isolated xenohepatocytes (group 3) was carried out as an adjuvant therapy in 61 patients with pyoseptic diseases. Control group consisted of 21 patients. Comparative analysis of effectiveness of the treatment showed, that in patients of group 2 after 5 days substantial increase of lymphocytes count was detected due to increased pool of T- and B-lymphocytes. In patients of group 1 increase in lymphocytes content occurred even in greater degree, but it occurred mainly owing to the augmentation of B-lymphocytes pool. In patients of groups 1 and 2 already to the 3rd day an increase of FAL as well IgA and IgM occurred. There was no immunocorrective effect in patients of group 3, as well as control group. However, detoxication activity, having been evaluated by bilirubin and cytolytic enzymes dynamics, by urea and kreatinine level increased in all patients of groups 1, 2, 3 in comparison with the control. It is suggested, that allogenic placental tissue could be recommended for the treatment of pyoseptic conditions, especially in patients with transplanted organs, because this tissue electively activates only humoral immunity.
Subject(s)
Liver/physiology , Placenta/physiology , Sepsis/therapy , Sorption Detoxification/methods , Spleen/physiology , Adolescent , Adult , Aged , B-Lymphocytes/immunology , Female , Humans , Liver Transplantation/immunology , Male , Middle Aged , Pregnancy , Sepsis/immunology , Spleen/transplantation , Suppuration/immunology , Suppuration/therapy , T-Lymphocytes/immunology , Treatment OutcomeABSTRACT
Hemoperfusion via donor hepatocytes and splenic fragments is an effective adjuvant method of treatment of hepatic insufficiency, especially in patients with autoimmune disease. Hemoperfusion effect occurs due to normalization of mesenchymoinflammatory and immunological indices as a result of positive action of hepatotropic and immunotropic factors of the spleen. The highest effectiveness of the above hemoperfusion is reached in its early use, that is before the disease becoming chronic.
Subject(s)
Autoimmune Diseases/therapy , Hemoperfusion/methods , Liver Failure/therapy , Autoimmune Diseases/etiology , Autoimmune Diseases/immunology , Autoimmune Diseases/physiopathology , Chronic Disease , Combined Modality Therapy , Evaluation Studies as Topic , Hemoperfusion/adverse effects , Hepatitis, Chronic/complications , Hepatitis, Chronic/immunology , Hepatitis, Chronic/physiopathology , Hepatitis, Chronic/therapy , Humans , Hypertension, Portal/complications , Hypertension, Portal/immunology , Hypertension, Portal/physiopathology , Hypertension, Portal/therapy , Liver/physiopathology , Liver Cirrhosis, Biliary/complications , Liver Cirrhosis, Biliary/immunology , Liver Cirrhosis, Biliary/physiopathology , Liver Cirrhosis, Biliary/therapy , Liver Failure/etiology , Liver Failure/immunology , Liver Failure/physiopathology , Remission Induction , SpleenSubject(s)
Energy Metabolism , Heart/physiopathology , Mitral Valve Stenosis/physiopathology , Myocardium/enzymology , Cardiac Catheterization , Coronary Circulation , Heart Ventricles/drug effects , Heart Ventricles/physiopathology , Hemodynamics/drug effects , Humans , Isoproterenol , Mitral Valve Stenosis/diagnosisSubject(s)
Analgesia/methods , Analgesics/administration & dosage , Neoplasms/therapy , Pain, Intractable/therapy , Adolescent , Adult , Aged , Female , Humans , Male , Middle Aged , Palliative CareABSTRACT
The urine content of catecholamines and their precursors was studied in lineal rats subjected to heterotopic heart allotransplantation, the dynamics being traced from 3 days preoperatively and throughout the period of transplant function (6.8 +/- 0.8 days, on the average). Heterotopic heart allotransplantation was shown to activate the sympathetic link of the sympathoadrenal system.
