[Neurovascular syndrome in some rheumatic diseases]. / Neirososudistyi sindrom pri nekotorykh revmaticheskikh zabolevaniiakh.

AIM: Assessment of neuromotor system and suprasegmentary vegetative structures in patients with systemic vasculitis (SV), systemic lupus erythematosus (SLE), scleroderma systematica (SS) for determination of the vegetative profile and pathogenetic links underlying vegetative disorders. MATERIALS AND METHODS: The examination of 125 rheumatic patients included clinical, laboratory, instrumental, neurological, neuropsychic, electroneuromyographic, vegetologic, pathomorphologic and biochemical investigations. RESULTS: Rheumatic patients presented affections of the peripheral and central venous systems, vegetative dysfunction, disturbed higher nervous activity manifesting as polyneuropathy, mononeuropathy, pyramid syndrome, dystonia, hypothalamic syndrome, reduced adaptive ability, low tonicity of the sympathetic nervous system, terminal branches of the motor axons, etc. CONCLUSION: Therapy of nervous disorders in rheumatic patients comprises treatment of cerebral circulation (vascular, nootropic drugs, cerebrolysin), asthenic, neurotic and vegetative disorders (sedative and vegetotropic drugs, etimisol, adaptogens), abnormalities of peripheral nervous system (amiridin, anticholinesterase preparations, vitamins B and others). Follow-up and correction of the on-going therapy contribute to a decrease in the number of invalidating and lethal neurological complications.

[Functional activity of polymorphonuclear leukocytes in systemic lupus erythematosus and periarteritis nodosa]. / Funktsional'naia aktivnost' polimorfno-iadernykh leikotsitov pri sistemnoi krasnoi volchanke i uzelkovom periarteriite.

The functional activity of polymorphonuclear leukocytes (PMNL) was studied in the test of biochemical luminescence (BCL) in 43 patients including 31 patients with systemic lupus erythematosus (SLE) and 12 with nodular periarteritis (NP). Generation of the active forms of oxygen depended on the activity of the pathological process and the level of the circulating immune complexes (CIC). As established, under the conditions of hyperproductions IC PMNL in patients with SLE and NP preserve a rather high capacity to generate active forms of oxygen into intracellular space that allows one to speak about the role of oxygen radicals in the development of vascular lesions in patients with rheumatic diseases.

[Free radicals of oxygen and their effect on inflammation mediators in patients with systemic lupus erythematosus]. / Svobodnye radikaly kisloroda i ikh vliianie na mediatory vospaleniia u bol'nykh sistemnoi krasnoi volchankoi.

The active forms of oxygen (AFA) participate in modulation of mediation processes in patients with systemic lupus erythematosus. A direct correlation of AFA with serotonin and kallikrein was noted, a reverse one with the inhibitory systems. Reactivity of AFA proved to be most marked in patients with lupus nephritis. The role of polymorphonuclear leukocytes in the activation of vasculo-thrombocytic hemostasis is discussed.

[Prostaglandins in the pathogenesis of vascular lesions in patients with rheumatic diseases]. / Prostaglandiny v patogeneze sosudistykh porazhenii u bol'nykh revmaticheskimi zabolevaniiami.

Using the radioimmunological method the authors studied the level of prostaglandins (PG) E and F2 alpha in 76 patients with rheumatic diseases (RD) including 34 with various forms of systemic vasculitis (SV), 30 with systemic lupus erythematosus (SLE) and 12 with systemic sclerodermia (SSD). The condition of the microcirculatory bed was assessed by the method of bulbar angioscopy. A relationship between PG and first of all the pressor series, and the nature of vascular lesions in patients with RD was established. Hyperproduction of PGE was revealed in patients with lupus nephritis and SV in whom diseases ran their course with involvement of the kidneys and the nervous system. The level of PGF2 alpha correlated with the markedness of vascular disorders in patients with ischemic and vasospastic syndromes as well as with skin forms of vasculitis in SLE.

[Correction of microcirculatory disorders in rheumatic diseases]. / Korrektsiia narusheniia mikrotsirkuliatsii pri revmaticheskikh zabolevaniiakh.

The present article is concerned with the problems of pharmacotherapy of microcirculatory disorders (MD) in rheumatic diseases (RD) and with the complex of methods permitting one to judge the intensity of the pathological process at the microcirculatory level. Based on the study of the problems of the correction of MD in more than 300 patients with RD the vasospastic, ischemic, cutaneotrophic, renal and pulmorenal syndromes as well as the DIC syndrome were recognized which require the correction therapy. Differentiated therapy including heparin, deaggregating agents, rheopolyglucin and peripheral vasodilators should be performed with regard to the degree of blood rheological properties derangement and tendency of alterations in the hemostatic potential. To evaluate the treatment, efficacy, biomicroscopy of the vessels of the eyeball conjunctiva and laboratory standardized methods for hemostasis study are the most available techniques.