Search | VHL Regional Portal

Morphology of endocrine organs in chronic endogenous intoxication.

Kalashnikova, S A; Polyakova, L V; Shchyogolev, A I.

Bull Exp Biol Med ; 151(2): 247-9, 2011 Jun.

Article in English | MEDLINE | ID: mdl-22238761

ABSTRACT

Experimental study of the effects of endogenous toxic compounds on endocrine organs showed that the pathomorphological changes were caused by the cytopathic effects of endogenous toxic compounds involving the development of stereotypical reactions to injury. The severity of these reactions depended on the initial functional status of the gland and its involvement in systemic mechanisms of adaptation to the toxic process.

Subject(s)

Endotoxemia/pathology , Adrenal Glands/immunology , Adrenal Glands/metabolism , Adrenal Glands/pathology , Animals , Caspase 3/metabolism , Cell Count , Edema/immunology , Endocrine System/immunology , Endocrine System/pathology , Endothelial Cells/metabolism , Endotoxemia/immunology , Female , Inflammation/immunology , Islets of Langerhans/immunology , Islets of Langerhans/pathology , Lipopolysaccharides/pharmacology , Liver/immunology , Liver/pathology , Male , Nitric Oxide Synthase Type III/metabolism , Paraventricular Hypothalamic Nucleus/immunology , Paraventricular Hypothalamic Nucleus/pathology , Pituitary Gland, Anterior/immunology , Pituitary Gland, Anterior/metabolism , Pituitary Gland, Anterior/pathology , Rats , TNF-Related Apoptosis-Inducing Ligand/metabolism , Thyroid Gland/immunology , Thyroid Gland/pathology

ABSTRACT

Subject(s)

SEND TO:

SELECTION OF CITATIONS

SEARCH DETAIL