ABSTRACT
The development of spontaneous mammary carcinoma in C3H mice is mainly attributed to an oncogenic virus (MMTV) and the high prolactin levels of this inbred strain. Interferon (IFN) reduces the incidence of mammary carcinoma in virgin C3H mice when administered during lactation. Bromocriptine LA, an antiprolactin drug, also decreases the incidence of this tumor in C3H mice. The combined action of mouse IFN-alpha + beta and bromocriptine LA had a significant anticarcinogenic effect more significant than either of the above agents administered independently. This antitumor action was effective in virgin C3H mice only.
Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Mammary Neoplasms, Experimental/prevention & control , Animals , Bromocriptine/administration & dosage , Delayed-Action Preparations , Female , Interferons/administration & dosage , Mammary Neoplasms, Experimental/genetics , Mice , Mice, Inbred C3HABSTRACT
The authors present an experimental study of the vascularization of the gallbladder, which was conducted by means of corrosion casting technique. Casts of the vessels of all calibers of 20 gallbladders were prepared. Our observations concern the morphology of the arteries and the veins of the gallbladder, the architecture of the fine vessels of the microcirculation, the vascular communications between the gallbladder and the proximal part of the liver and, also, the vessels of the latter.
Subject(s)
Gallbladder/blood supply , Adolescent , Adult , Aged , Autopsy , Child , Female , Gallbladder/anatomy & histology , Humans , Male , Middle AgedABSTRACT
A morphologically distinctive lesion similar to fibroadenomas in female breast was found in 12 cases of benign prostatic hyperplasia out of 1356 prostatic specimens examined. All of them were from patients older than 60 years of age, and none from either normal or carcinomatous prostates. A possible pathogenetic interrelationship between the prostatic lesion and the fibroadenomas of female breast is discussed.
Subject(s)
Adenofibroma/pathology , Breast Neoplasms/pathology , Prostatic Hyperplasia/pathology , Aged , Female , Humans , Male , Middle AgedABSTRACT
The ultrastructure of the Guérin tumour T-8 is described. Although this transplantable tumour has its ancestry in an uterine adenocarcinoma, there is no more evidence of gland formation. Desmosomes, or any other form of cell attachment organelle, were totally absent. The tumour has now a very anaplastic sarcomatous appearance.
