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1.
Int J Gynecol Cancer ; 24(1): 48-53, 2014 Jan.
Article in English | MEDLINE | ID: mdl-24356411

ABSTRACT

OBJECTIVE: The aim of the study was to report on the oncologic outcome of the disease spread to celiac lymph nodes (CLNs) in advanced-stage ovarian cancer patients. METHODS: All patients who had CLN resection as part of their cytoreductive surgery for epithelial ovarian, fallopian, or primary peritoneal cancer were identified. Patient demographic data with particular emphasis on operative records to detail the extent and distribution of the disease spread, lymphadenectomy procedures, pathologic data, and follow-up data were included. RESULTS: The median follow-up was 26.3 months. The median overall survival values in the group with positive CLNs and in the group with negative CLNs were 26.9 months and 40.04 months, respectively. The median progression-free survival values in the group with metastatic CLNs and in the group with negative CLNs were 8.8 months and 20.24 months, respectively (P = 0.053). Positive CLNs were associated with progression during or within 6 months after the completion of chemotherapy (P = 0.0044). Tumor burden and extensive disease distribution were significantly associated with poor progression-free survival, short-term progression, and overall survival. In multivariate analysis, only the CLN status was independently associated with short-term progression. CONCLUSIONS: Disease in the CLN is a marker of disease severity, which is associated to a high-risk group of patients with presumed adverse tumor biology, increased risk of lymph node progression, and worst oncologic outcome.


Subject(s)
Lymph Nodes/pathology , Ovarian Neoplasms/pathology , Adult , Aged , Disease-Free Survival , Female , France/epidemiology , Humans , Lymphatic Metastasis , Middle Aged , Ovarian Neoplasms/mortality , Retrospective Studies , Young Adult
2.
Am J Surg ; 194(2): 164-9, 2007 Aug.
Article in English | MEDLINE | ID: mdl-17618797

ABSTRACT

BACKGROUND: Immediate breast reconstruction using the latissimus dorsi musculocutaneous flap is a standard technique that allows for cosmetically acceptable results yet leaves a great scar on the donor site. To reduce the scars, we have been using a different surgical technique consisting of endoscopic harvesting of the latissimus dorsi pure muscular flap with a virtual cavity created by CO2 gas distention. METHODS: Between May 1, 2001, and June 30, 2005, there were 52 patients who underwent latissimus dorsi endoscopic harvesting for an immediate breast reconstruction after a skin-sparing mastectomy. RESULTS: The mean surgical endoscopic time was 64 minutes. There was one conversion to an open technique. We reported no deaths, but complications included 2 hematomas, 6 inflammatory syndromes, and 1 pulmonary embolism. CONCLUSIONS: The endoscopic harvesting of the latissimus dorsi flap when performed with this mixed technique is feasible, reproducible, and permits a significant reduction of incision size and postoperative pain, with good aesthetic results.


Subject(s)
Endoscopy , Mammaplasty/methods , Muscle, Skeletal/surgery , Surgical Flaps , Tissue and Organ Harvesting/methods , Adult , Breast Neoplasms/surgery , Carcinoma/surgery , Female , Follow-Up Studies , Humans , Mastectomy , Middle Aged , Retrospective Studies , Treatment Outcome
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