Adaptation to spanish and validation of the sport team socialization tactics questionnaire / Adaptación y validación al español del cuestionario de tácticas de socialización para equipos deportivos

The aim of the study was to adapt and validate the Sport Team Socialization Tactics Questionnaire (STSTQ) with amateur and semi-professional Spanish players. The participants were 437 male and female players aged 15 to 39 (M = 21.90; SD = 5.67). Confirmatory factor analysis was applied to test the three-factor structure: coach-initiated role communication tactics, serial socialization tactics and social inclusionary tactics. According to the results, the Spanish version of the STSTQ presented adequate index values in its original factor structure and acceptable internal consistency values. Moreover, the instrument presented adequate discriminating and concurrent validity and proved to be invariant regardless of the competitive level. These results suggest that the Spanish version of the STSTQ is a valid and reliable tool to assess socialization tactics in amateur and semi-professional team sports. (AU)

El objetivo del estudio era adaptar y validar el Cuestionario de Tácticas de Socialización para Equipos Deportivos (en inglés Sport Team Socialization Tactics Questionnarie, STSTQ) con jugadores españoles amateurs y semi-profesionales. Participaron 437 jugadores de fútbol de género masculino y femenino con edades comprendidas entre los 15-39 años (M = 21,90; DT = 5,67). Se realizó un análisis factorial confirmatorio para testar la estructura factorial compuesta por tres factores: tácticas de comunicación del rol del entrenador, tácticas de socialización en serie y tácticas sociales de inclusión. Los resultados mostraron que la versión española del STSTQ demuestra índices adecuados en su estructura factorial original y valores aceptables de consistencia interna. Además, el instrumento presentó una adecuada validez discriminante y concurrente y se mostró invariante en función del nivel competitivo. Estos resultados sugieren que la versión española del STSTQ es una herramienta válida y fiable para medir las tácticas de socialización en deportes colectivos amateurs y semi-profesionales. (AU)

Análisis de las acciones técnico-tácticas del portero de fútbol en competición / Analysis of the technical-tactical actions by goalkeeper on football in competition

El objetivo del presente estudio fue analizar las diferencias en el número y tipo de acciones técnico-tácticas de los porteros en competición en función de la división y de si juegan como local o visitante. Para ello, se han analizado 80 partidos con un total de 160 porteros de 1ª, 2ª, 2ªB y 3ª división española. Los resultados mostraron que no existen diferencias significativas entre el número de acciones medias realizadas por partido en cada división, pero sí se encontraron diferencias significativas en 9 de los 48 gestos técnico-tácticos específicos estudiados. Además, se encontraron pequeñas diferencias en cuanto al número de acciones en función de si los porteros juegan como local o visitante. Por tanto, la principal conclusión de este estudio es la importancia de analizar los tipos de acciones técnico-tácticas de los porteros ya que nos pueden ofrecer información relevante para el entrenamiento y la competición

The present study tries to respond about three different objectives: a) to quantify the number of technical-tactical actions carried out by goalkeepers during matches and to analyze if there are differences between divisions, b) to examine the possible differences in the number and type of technical-tactical actions between divisions under investigation, and c) to analyze the differences between this number and the type of technical-tactical actions when goalkeepers play at home team or away teams . To this end, a viewing was made of the 80 matches of the four most important divisions of Spanish football and a total of 160 goalkeepers were analyzed using the observational methodology. After the application of the tests the H-test of Krustal-Wallis and U of Mann-Whitney, showed no significant differences between the number of average actions performed per game in each division. Only significant differences were found in 9 of the 48 specific technical-tactical gestures studied. So, the first conclusion in this study is the importance of analyzing the types of technical-tactical actions of goalkeepers, due to they can offer relevant information for training and competition

A systems genomics approach identifies SIGLEC15 as a susceptibility factor in recurrent vulvovaginal candidiasis.

Candida vaginitis is a frequent clinical diagnosis with up to 8% of women experiencing recurrent vulvovaginal candidiasis (RVVC) globally. RVVC is characterized by at least three episodes per year. Most patients with RVVC lack known risk factors, suggesting a role for genetic risk factors in this condition. Through integration of genomic approaches and immunological studies in two independent cohorts of patients with RVVC and healthy individuals, we identified genes and cellular processes that contribute to the pathogenesis of RVVC, including cellular morphogenesis and metabolism, and cellular adhesion. We further identified SIGLEC15, a lectin expressed by various immune cells that binds sialic acid-containing structures, as a candidate gene involved in RVVC susceptibility. Candida stimulation induced SIGLEC15 expression in human peripheral blood mononuclear cells (PBMCs) and a polymorphism in the SIGLEC15 gene that was associated with RVVC in the patient cohorts led to an altered cytokine profile after PBMC stimulation. The same polymorphism led to an increase in IL1B and NLRP3 expression after Candida stimulation in HeLa cells in vitro. Last, Siglec15 expression was induced by Candida at the vaginal surface of mice, where in vivo silencing of Siglec15 led to an increase in the fungal burden. Siglec15 silencing was additionally accompanied by an increase in polymorphonuclear leukocytes during the course of infection. Identification of these pathways and cellular processes contributes to a better understanding of RVVC and may open new therapeutic avenues.

Athletes' perceptions of coaching competency and team conflict in sport teams: A multilevel analysis.

The purpose of this study was to examine the relationship between coaching competency and team conflict, at individual and team levels, over the season. The participants were professional female and male soccer players, who participated in the First and Second Division. A longitudinal study was performed. At Time 1, the sample of participants consisted of 581 soccer players aged between 15 and 39 years. At Time 2, 549 players were recruited from the original sample aged between 15 and 37 years. Finally, at Time 3, the sample comprised 576 players aged between 15 and 37 years. All participants completed a multi-section questionnaire assessing coaching competency (motivation, game strategy, technique competency, and character-building competency) and team conflict (task conflict and relationship conflict). Results showed that both task and relationship conflict increased significantly over time. Multilevel modelling analysis showed that game strategy and character-building competencies negatively predicted both task and relationship conflicts at the individual level, whereas motivation competency was also added as a significant predictor of task conflict at the team level. Moreover, technique competency positively predicted task conflict at the team level. The current study suggests the importance of coaching competency in group dynamics in sport.

Immunochip analysis identifies novel susceptibility loci in the human leukocyte antigen region for acquired thrombotic thrombocytopenic purpura.

Essentials Genetic predisposition to acquired thrombotic thrombocytopenic purpura (aTTP) is mainly unknown. Genetic risk factors for aTTP were studied by Immunochip analysis and replication study. Human leukocyte antigen (HLA) variant rs6903608 conferred a 2.5-fold higher risk of developing aTTP. rs6903608 and HLA-DQB1*05:03 may explain most of the HLA association signal in aTTP. Click to hear Dr Cataland's presentation on acquired thrombotic thrombocytopenic purpura SUMMARY: Background Acquired thrombotic thrombocytopenic purpura (TTP) is a rare, life-threatening thrombotic microangiopathy associated with the development of autoantibodies against the von Willebrand factor-cleaving protease ADAMTS-13. Similarly to what has been found for other autoimmune disorders, there is evidence of a genetic contribution, including the association of the human leukocyte antigen (HLA) class II complex with disease risk. Objective To identify novel genetic risk factors in acquired TTP. Patients/Methods We undertook a case-control genetic association study in 190 European-origin TTP patients and 1255 Italian healthy controls by using the Illumina Immunochip. Replication analysis in 88 Italian cases and 456 controls was performed with single-nucleotide polymorphism (SNP) TaqMan assays. Results and conclusion We identified one common variant (rs6903608) located within the HLA class II locus that was independently associated with acquired TTP at genome-wide significance and conferred a 2.6-fold increased risk of developing a TTP episode (95% confidence interval [CI] 2.02-3.27, P = 1.64 × 10-14 ). We also found five non-HLA variants mapping to chromosomes 2, 6, 8 and X that were suggestively associated with the disease: rs9490550, rs115265285, rs5927472, rs7823314, and rs1334768 (nominal P-values ranging from 1.59 × 10-5 to 7.60 × 10-5 ). Replication analysis confirmed the association of HLA variant rs6903608 with acquired TTP (pooled P = 3.95 × 10-19 ). Imputation of classic HLA genes followed by stepwise conditional analysis revealed that the combination of rs6903608 and HLA-DQB1*05:03 may explain most of the HLA association signal in acquired TTP. Our results refined the association of the HLA class II locus with acquired TTP, confirming its importance in the etiology of this autoimmune disease.

Expression, functionality, and localization of apurinic/apyrimidinic endonucleases in replicative and non-replicative forms of Trypanosoma cruzi.

Trypanosoma cruzi is the etiological agent of Chagas disease. The parasite has to overcome oxidative damage by ROS/RNS all along its life cycle to survive and to establish a chronic infection. We propose that T. cruzi is able to survive, among other mechanisms of detoxification, by repair of its damaged DNA through activation of the DNA base excision repair (BER) pathway. BER is highly conserved in eukaryotes with apurinic/apirimidinic endonucleases (APEs) playing a fundamental role. Previous results showed that T. cruzi exposed to hydrogen peroxide and peroxinitrite significantly decreases its viability when co-incubated with methoxyamine, an AP endonuclease inhibitor. In this work the localization, expression and functionality of two T. cruzi APEs (TcAP1, Homo sapiens APE1 orthologous and TcAP2, orthologous to Homo sapiens APE2 and to Schizosaccaromyces pombe Apn2p) were determined. These enzymes are present and active in the two replicative parasite forms (epimastigotes and amastigotes) as well as in the non-replicative, infective trypomastigotes. TcAP1 and TcAP2 are located in the nucleus of epimastigotes and their expression is constitutive. Epimastigote AP endonucleases as well as recombinant TcAP1 and TcAP2 are inhibited by methoxyamine. Overexpression of TcAP1 increases epimastigotes viability when they are exposed to acute ROS/RNS attack. This protective effect is more evident when parasites are submitted to persistent ROS/RNS exposition, mimicking nature conditions. Our results confirm that the BER pathway is involved in T. cruzi resistance to DNA oxidative damage and points to the participation of DNA AP endonucleases in parasite survival.

Exome sequencing in a family segregating for celiac disease.

Celiac disease is a multifactorial disorder caused by an unknown number of genetic factors interacting with an environmental factor. Hence, most patients are singletons and large families segregating with celiac disease are rare. We report on a three-generation family with six patients in which the inheritance pattern is consistent with an autosomal dominant model. To date, 27 loci explain up to 40% of the heritable disease risk. We hypothesized that part of the missing heritability is because of low frequency or rare variants. Such causal variants could be more prominent in multigeneration families where private mutations might co-segregate with the disease. They can be identified by linkage analysis combined with whole exome sequencing. We found three linkage regions on 4q32.3-4q33, 8q24.13-8q24.21 and 10q23.1-10q23.32 that segregate with celiac disease in this family. We performed exome sequencing on two affected individuals to investigate the positional candidate regions and the remaining exome for causal nonsense variants. We identified 12 nonsense mutations with a low frequency (minor allele frequency <10%) present in both individuals, but none mapped to the linkage regions. Two variants in the CSAG1 and KRT37 genes were present in all six affected individuals. Two nonsense variants in the MADD and GBGT1 genes were also present in 5 of 6 and 4 of 6 individuals, respectively; future studies should determine if any of these nonsense variants is causally related to celiac disease.

[Follicular unit hair transplantation: current technique]. / Técnica actual del trasplante de pelo de unidades foliculares.

UNLABELLED: Since 1959, when Norman Orentreich described the phenomenon of donor dominance in androgenic alopecia and opened the way to hair transplantation, the field of hair replacement surgery has been evolving continuously. Advances in the last 15 years, particularly the microscopic dissection of donor strips into follicular units, have eradicated the idea that follicular transplantation is an aggressive procedure that produces an artificial result. Hair transplantation procedures involving the transplant of only follicular units can now achieve natural, undetectable, and reproducible RESULTS: , very different from the outcomes achieved with earlier techniques. Consequently, there is no excuse today for not offering hair transplantation to patients with androgenic alopecia, both male and female, who are good candidates for this technique. This review provides a general overview of the current procedure for follicular unit hair transplantation.

Técnica actual del trasplante de pelo de unidades foliculares / Follicular Unit Hair Transplantation: Current Technique

Desde que en 1959 Norman Orentreich describiera el fenómeno de dominancia donante en la alopecia androgenética, abriendo así el camino a los trasplantes capilares, el campo del trasplante de pelo ha estado en permanente evolución. Con los avances surgidos en estos últimos 15 años, principalmente con la disección microscópica de los injertos en unidades foliculares, se ha conseguido desterrar la idea de que el trasplante es una técnica agresiva que produce un resultado artificial. Gracias al uso exclusivo de unidades foliculares como el único elemento de trasplante, el trasplante de pelo se ha convertido en una técnica con resultados naturales, indetectables y reproducibles, muy diferentes a los alcanzados con las técnicas anteriores. Por todo ello, hoy día no existe excusa para dejar de ofrecer la posibilidad del trasplante a aquellos pacientes con alopecia androgenética, tanto hombres como mujeres, que sean buenos candidatos al mismo. En este artículo de revisión describimos de forma general el procedimiento actual del trasplante de pelo con unidades foliculares (AU)

Since 1959, when Norman Orentreich described the phenomenon of donor dominance in androgenic alopecia and opened the way to hair transplantation, the field of hair replacement surgery has been evolving continuously. Advances in the last 15 years, particularly the microscopic dissection of donor strips into follicular units, have eradicated the idea that follicular transplantation is an aggressive procedure that produces an artificial result. Hair transplantation procedures involving the transplant of only follicular units can now achieve natural, undetectable, and reproducible results, very different from the outcomes achieved with earlier techniques. Consequently, there is no excuse today for not offering hair transplantation to patients with androgenic alopecia, both male and female, who are good candidates for this technique. This review provides a general overview of the current procedure for follicular unit hair transplantation (AU)

Trasplante de pelo en la alopecia temporal triangular / Hair Transplantation in Triangular Temporal Alopecia

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Density functional theory study of the nematic-isotropic transition in an hybrid cell.

We have employed the density functional theory formalism to investigate the nematic-isotropic capillary transitions of a nematogen confined by walls that favor antagonist orientations to the liquid crystal molecules (hybrid cell). We analyze the behavior of the capillary transition as a function of the fluid-substrate interactions and the pore width. In addition to the usual capillary transition between isotropiclike to nematiclike states, we find that this transition can be suppressed when one substrate is wet by the isotropic phase and the other by the nematic phase. Under this condition the system presents interfacelike states which allow us to continuously transform the nematiclike phase to the isotropiclike phase without undergoing a sharp phase transition. Two different mechanisms for the disappearance of the capillary transition are identified. When the director of the nematiclike state is homogeneously planar-anchored with respect to the substrates, the capillary transition ends up in a critical point. This scenario is analogous to the observed in Ising models when confined in slit pores with opposing surface fields which have critical wetting transitions. When the nematiclike state has a linearly distorted director field, the capillary transition continuously transforms in a transition between two nematiclike states.

Algunos factores de riesgo de la desnutrición proteicoenergética / Some risk factors of protein-energy malnutrition

Con el objetivo de analizar la influencia de algunos factores de riesgo sobre la desnutrición proteicoenergética se llevó a cabo un estudio de casos y controles en la policlínica 'Luis Enrique de la Paz' de Yara, Cuba, durante el año 2001. Los casos se constituyeron por 34 niños menores de 15 años, para los que se seleccionaron 68 controles; los datos se organizaron en tablas de contingencias y se realizaron cálculos estadísticos a través del 2 y el OR, con sus intervalos de confianza, además del coeficiente de correlación . Los resultados ubicaron a la estrechez económica de vida en el primer lugar (OR= 9,50).Mejorando esta condición se reduciría la desnutrición proteicoenergética en un 89 por ciento; le siguió en orden de importancia el parasitismo intestinal (OR= 7,27), identificado también como factor de riesgo, al igual que las infecciones respiratorias repetidamente y el bajo nivel de instrucción de los padres. Se correlacionó moderadamente la estrechez económica de vida con el parasitismo y el nivel de instrucción. Una vez identificado el riesgo será posible establecer pautas preventivas para disminuir la incidencia de este morboso proceso (AU)

Orientational transitions in a nematic liquid crystal confined by competing surfaces.

The effect of confinement on the orientational structure of a nematic liquid crystal model has been investigated by using a version of density-functional theory. We have focused on the case of a nematic confined by opposing flat surfaces, in slab geometry (slit pore), which favor planar molecular alignment (parallel to the surface) and homeotropic alignment (perpendicular to the surface), respectively. The spatial dependence of the tilt angle of the director with respect to the surface normal has been studied, as well as the tensorial order parameter describing the molecular order around the director. For a pore of given width, we find that, for weak surface fields, the alignment of the nematic director is perpendicular to the surface in a region next to the surface favoring homeotropic alignment, and parallel along the rest of the pore, with a sharp interface separating these regions (S phase). For strong surface fields, the director is distorted uniformly, the tilt angle exhibiting a linear dependence on the distance normal to the surface (L phase). Our calculations reveal the existence of a first-order transition between the two director configurations, which is driven by changes in the surface field strength, and also by changes in the pore width. In the latter case the transition occurs, for a given surface field, between the S phase for narrow pores and the L phase for wider pores. A link between the L-S transition and the anchoring transition observed for the semi-infinite case is proposed.

Complement factor I deficiency associated with recurrent meningitis coinciding with menstruation.

BACKGROUND: Complement (C) factor I deficiency is a rare immunodeficiency state frequently associated with recurrent pyogenic infections in early infancy. This deficiency causes a permanent uncontrolled activation of the alternative pathway resulting in massive consumption of C3. PATIENT: A 23-year-old woman with monthly recurrent meningitis episodes, mostly in the perimenstrual period, since August 1999. Previously, at age 16 years, she had meningococcal sepsis, also coinciding with menstruation. OBJECTIVES: To study the patient and her family to elucidate the molecular defects in the pedigree and to evaluate her clinical evolution. RESULTS: We describe clinical, immunological, and treatment follow-up during this period. First, we characterized the existence of a total complement factor I deficiency defined by undetectable levels by enzyme immunosorbent assay. This total deficiency was also found in her sister. Her parents and brother had approximately half of the normal levels. In addition, the patient had very low levels of C3; factor B; and an important reduction of factor H, properdin, C5, C7, and C8 complement components. Additional studies in the patient's sera evidenced high levels of immune complexes containing C1q and immunoglobulin (Ig) G, as well as C3b/factor H, C3b/properdin, C3b/IgG, and properdin/IgG complexes. Treatment with prophylactic antibiotics, antiestrogen medication, plasma infusions, or intravenous immunoglobulin has been unsuccessful in avoiding consecutive meningitis episodes. CONCLUSION: For the first time to our knowledge, these data present an unusual relationship between meningitis episodes and menstruation in factor I immunodeficiency.

Cáncer de cérvix. ¿Enfermedad oncológica o enfermedad infecciosa? / No disponible

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Porphyria cutanea tarda and human immunodeficiency virus infection.

Porphyria cutanea tarda (PCT), a relatively uncommon disease, has recently been reported in patients infected with the human immunodeficiency virus (HIV). Although PCT and HIV infection may co-exist by chance, the increasing number of reported cases suggest that HIV or an associated factor triggers the development of PCT in predisposed individuals. We report four additional cases of PCT in HIV seropositive patients and review the previously reported cases. The possible links between PCT and HIV are discussed. We believe the diagnosis of PCT should prompt investigation for HIV infection in all patients.

Hernia inguinal y ocupación laboral / Inguinal hernia and labor occupation

Se hace un estudio de 266 pacientes operados por hernia inguinal en nuestro hospital en el período de un año. Se investigan sexo y edades más frecuentes, relación de aparición de la hernia con esfuerzos físicos grandes, actividad laboral que desempeña, práctica de deportes, tipo de hernia que presenta, etc., encontrándose que es más frecuente en los hombres mayores de 65 años, y que en la mayoría se presentó después de un esfuerzo físico no habitual y en enfermos que realizan una actividad laboral que no requiere de dichos esfuerzos; también, en su inmensa mayoría, no practican deportes. La hernia inguinal indirecta fue la más frecuente en nuestro estudio (AU)