ABSTRACT
Results of a preclinical study of the anxiolytic activity and safety of original Racium phytomedicine are presented. The preparation possessed high anxiolytic activity, exhibits a wide range of therapeutic effects, produces no lethality in male and female rats and mice upon single intragastric and intraperitoneal introduction in doses up to 5 g/kg (VI class of toxicity according to OECD), induces no pathologic effects upon prolonged (120 days) administration in these rodents, and has no local irritant and/or allergen action.
Subject(s)
Anti-Anxiety Agents/therapeutic use , Anxiety/drug therapy , Melissa/chemistry , Mentha piperita/chemistry , Phytotherapy , Plant Extracts/therapeutic use , Valerian/chemistry , Animals , Anti-Anxiety Agents/administration & dosage , Anti-Anxiety Agents/chemistry , Anxiety/physiopathology , Anxiety/psychology , Chromatography, High Pressure Liquid , Dose-Response Relationship, Drug , Drug Evaluation, Preclinical , Drug-Related Side Effects and Adverse Reactions , Female , Injections, Intraperitoneal , Intubation, Gastrointestinal , Lethal Dose 50 , Male , Mice , Plant Extracts/administration & dosage , Plant Extracts/chemistry , Rats , Sesquiterpenes/analysisABSTRACT
The influence of the original dipeptide drug noopept, known to possess nootrope, neuroprotector, and anxiolytic properties, on the anticonvulsant activity of the antiepileptic drug valproate has been studied on the model of corazole-induced convulsions in mice. Neither a single administration of noopept (0.5 mg/kg, i.p.) nor its repeated introduction in 10 or 35 days enhanced the convulsant effect of corazole, which is evidence that noopept alone does not possess anticonvulsant properties. Prolonged (five weeks) preliminary administration of noopept enhanced the anticonvulsant activity of valproate. This result justifies the joint chronic administration of noopept in combination with valproate in order to potentiate the anticonvulsant effect of the latter drug. In addition, the administration of noopept favorably influences the cognitive functions and suppresses the development of neurodegenerative processes.
