ABSTRACT
The present study began in 1965 when South Trinidad experienced the third major epidemic of acute nephritis and extends over a twenty year period
Subject(s)
Humans , Nephritis , Streptococcal Infections , Trinidad and Tobago , West IndiesABSTRACT
A new mode of administering malaria chemotherapy to patients unable to tolerate oral medication is described. A patient with Plasmodium falciparum malaria, severe hyponatraemia and hypokalemia who regurgitated oral treatment of chloroquine phosphate and pyrimethamine and sulfadoxine (Fansidar) is presented. But neither chloroquine nor quinine intravenous formulations were available locally. As the patient was deteriorating, a suspension of chloroquine phosphate was prepared and administered rectally, resulting in a decline in the level of parasitaemia from ++++ to ++ within 48 hours. The patient improved, and further clinical management was uncomplicated (AU)
Subject(s)
Adult , Humans , CASE REPORT , Malaria, Falciparum/drug therapy , Trinidad and Tobago , Chloroquine/pharmacology , Administration, Rectal , Treatment Outcome , Caribbean Region , Hypokalemia/epidemiologyABSTRACT
The present study began in 1965 when South Trinidad experienced the third major epidemic of acute nephritis and extends over a twenty year period (AU)
Subject(s)
Humans , Nephritis/epidemiology , Streptococcal Infections/epidemiology , Trinidad and Tobago/epidemiology , West IndiesABSTRACT
The clinical, histopathological and serological findings in three patients who developed yellow fever after entering the Guayaguayare forest in south-east Trinidad in January and February 1979 are described in this report. The patients were all previously healthy young males and the clinical features of the disease varied from fulminant viral hepatitis with hepato-renal failure to a self-limiting anicteric viral illness. The first patient died, and histopathological examination of the liver was done post-mortem. Needle biopsy of the liver was done on Case 2 which presented with the clinical picture of infective hepatitis and on Case 3 with the features of an anicteric viral illness. The histopathological hallmarks of midzonal necrosis, granular eosinophilic degeneration (Councilman bodies) and fatty change in the parenchymal cells of the liver were seen in three c[a]ses. The electron microscope study demonstrated the presence of the yellow fever virus in the liver of the patient who died (AU)
