ABSTRACT
Twenty-five patients of intermittent acute porphyria (IAP) in latent period were studied neurophysiologically by assessing motor and sensory nerve conduction velocities, late responses (F-wave and H-reflex) and somatosensory evoked potentials of median nerve and were compared with 15 age and sex matched control group. All the patients had at least one classical attack of IAP during which Watson Schwartz test was positive. None of them had any evidence of neurological defecit at the time of examination. Compared with the controls, patients of AIP had significantly slower motor and sensory conduction velocities of median nerve (P < 0.001) and it was more marked in the distal segment of the nerve. Nineteen out of 25 had one or the other abnormal neurophysiological parameter. Reduced nerve conduction velocity was not found to have any relation with age, sex or duration of the illness or number of attacks. Present study shows evidence of subclinical neuropathy in patients of intermittent acute porphyria in latent phase.
Subject(s)
Evoked Potentials, Somatosensory/physiology , H-Reflex/physiology , Motor Neurons/physiology , Porphyria, Acute Intermittent/diagnosis , Reaction Time/physiology , Sensory Receptor Cells/physiology , Synaptic Transmission/physiology , Adolescent , Adult , Electric Stimulation , Female , Humans , Male , Median Nerve/physiopathology , Middle Aged , Porphyria, Acute Intermittent/physiopathology , Reference ValuesABSTRACT
Experimental model for chlamydial abortion was planned using pregnant guinea pigs to study whether the isolate of Chlamydia psittaci from natural cases of sheep abortion is able to cause experimental abortion in pregnant guinea pigs or not. Follow up and clinical observations like thermal reaction and haematological changes exhibited biphaic febrile response and marked leucopenia in both intraperitoneal group as well as intravaginal group. The laboratory examinations revealed presence of chlamydial intracytoplasmic inclusions in the impression smears of aborted foetal tissues. C. psittaci was reisolated successfully from all the aborted foetal tissues. It was observed that rate and severity of abortion were more in the intraperitoneal group as compared to intravaginal group. On correlating the results of clinical and laboratory examinations it was observed that guinea pig can be used as a suitable model for chlamydial abortion in future studies like cell mediate immune response and to see protective role of chlamydial vaccine, if any.
Subject(s)
Abortion, Veterinary/etiology , Chlamydophila psittaci/pathogenicity , Animals , Chlamydia Infections/pathology , Chlamydia Infections/physiopathology , Female , Guinea Pigs , Pregnancy , SheepSubject(s)
Malaria, Vivax/complications , Splenic Rupture/etiology , Acute Disease , Adult , Animals , Erythrocytes/parasitology , Humans , Male , Plasmodium vivax/isolation & purification , Spleen/diagnostic imaging , Spleen/pathology , Spleen/surgery , Splenectomy , Splenic Rupture/diagnosis , Splenic Rupture/surgery , UltrasonographyABSTRACT
A case of Meige's syndrome is reported who presented with blepharospasm and oromandibular dystonia along with dislocation of jaw, due to severe dystonia. Such severe form of dystonia are very rare.
