ABSTRACT
Three children, a girl aged 9 and two boys aged 2.5 and 6 years, presented with a stiff neck and fever. They had been treated for vomiting and diarrhoea with among other drugs metoclopramide or domperidone suppositories. As a result extrapyramidal signs had developed. These were cut by intravenous injection of biperiden. It is argued that gastroenteritis in children should be treated by oral rehydration only and that there is no place for antiemetics.
Subject(s)
Antiemetics/adverse effects , Basal Ganglia Diseases/chemically induced , Domperidone/adverse effects , Gastroenteritis/drug therapy , Metoclopramide/adverse effects , Antiemetics/administration & dosage , Basal Ganglia Diseases/diagnosis , Child , Child, Preschool , Diagnosis, Differential , Female , Humans , Male , Meningitis/diagnosis , Metoclopramide/administration & dosage , SuppositoriesABSTRACT
A 68-year-old man developed subacutely bilateral loss of visual acuity without any other neurological sign. Magnetic resonance images showed some small scattered periventricular white matter T2 hypersignals. On spinal fluid analysis a mononuclear pleocytosis and an oligoclonal gamma-pattern was found. Treatment with intravenous corticosteroids had no effect. The clinical situation deteriorated and the patient died of bronchopneumonia. Postmortem examination revealed manifest metastatic invasion of both the optic nerves by a non-detectable primary tumor.
Subject(s)
Cranial Nerve Neoplasms/secondary , Krukenberg Tumor/secondary , Neoplasms, Unknown Primary/diagnosis , Optic Nerve Diseases/diagnosis , Optic Neuritis/diagnosis , Aged , Cranial Nerve Neoplasms/diagnosis , Cranial Nerve Neoplasms/pathology , Diagnosis, Differential , Humans , Krukenberg Tumor/diagnosis , Krukenberg Tumor/pathology , Magnetic Resonance Imaging , Male , Neoplasm Invasiveness , Neoplasms, Unknown Primary/pathology , Optic Nerve/pathology , Optic Nerve Diseases/pathology , Optic Neuritis/pathologyABSTRACT
A 19-year-old woman presented with severe carbon monoxide poisoning resulting in coma, brain stem signs, cerebellar syndrome, anterograde memory disorder and some frontal signs. Nine years later, generalized seizures appeared. At the age of 31, the cerebellar syndrome and memory disorders persisted. MRI showed cerebellar and internal temporal atrophy with high-intensity signals, and hippocampal and callosal atrophy. SPECT (Xe133) showed a low cerebellar blood flow.
Subject(s)
Carbon Monoxide Poisoning/complications , Cerebellar Diseases/etiology , Adult , Atrophy , Cerebellar Diseases/diagnosis , Cerebellum/diagnostic imaging , Cerebellum/pathology , Female , Humans , Magnetic Resonance Imaging , Memory Disorders/etiology , Radiography , Tomography, Emission-Computed, Single-PhotonABSTRACT
A 32-year old woman presented with serious memory impairment and a mental syndrome named loss of psychic auto-activation or psychic akinesia following carbon monoxide poisoning. The MRI findings were bilateral pallidal lesions probably associated with thalamic lesions. The evolution was favourable.
Subject(s)
Carbon Monoxide Poisoning/complications , Memory Disorders/chemically induced , Substance-Related Disorders/etiology , Adult , Brain/pathology , Electroencephalography , Female , Humans , Magnetic Resonance Imaging , Neuropsychological Tests , Organotechnetium Compounds , Oximes , Substance-Related Disorders/diagnosis , Substance-Related Disorders/pathology , Technetium Tc 99m Exametazime , Tomography, Emission-ComputedABSTRACT
Several authors have reported the in vitro production of colony-stimulating factors (CSF) and interleukin-1 (IL-1) by the neoplastic cells from patients with acute myeloid leukemia (AML). Using a sensitive bioassay for IL-6, the capacity of the leukemic cells of 30 patients with AML to produce IL-6 was examined. IL-6 production was found to be specific for cells from patients with an AML with monocytic differentiation (12 of 15 M4 and M5 patients, 0 of 15 M1 and M2 patients). Moreover, IL-6 production was paralleled by IL-1 production. The IL-6- and IL-1-producing cells were mainly found in the more mature monocytic cell fractions, defined as CD14-positive and CD34-negative adherent cells. By limiting dilution experiments, it could be excluded that the production of IL-1 or IL-6 was due to contamination with normal monocytes.
