Kinetics of thermal decomposition of buspirone hydrochloride in solid state.

Stability of buspirone hydrochloride (BH) in solid state has been studied. The content of BH and changes in its concentration during preliminary kinetic studies of the stability of this drug in BUSPAR tablets and in substance were assessed by spectrophotometry in UV, after previous chromatographic separation lambda max = 239 nm (A1%1 cm = 502 in 50% aqueous methanol solution). Using thin layer chromatography several breakdown of buspirone were detected.