1.
Ukr Biokhim Zh (1999)
; 83(1): 30-7, 2011.
Article
in Russian
| MEDLINE
| ID: mdl-21800646
ABSTRACT
A series of 5-amino-1H-pyrazoles was synthesized and studied as inhibitors of furin. The most potent compound, 5-amino-4-acetylamino-3-(4-methylphenylamino)1H-pyrazole, was found to retard the activity of furin by mixed-type inhibition with K = 288 microM. These findings permit to plan new ways for chemical modifications of the 5-amino-1H-pyrazole structure and design more potent furin inhibitors of non-peptide nature.