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1.

Endotoxin inhibition of glucocorticoid enzyme induction and in vivo 3H-dexamethasone labelling of rat liver nuclei.

Vaptzarova, K I; Baramova, E N; Popov, P G.

Int J Biochem ; 21(6): 701-5, 1989.

Article in English | MEDLINE | ID: mdl-2571527

ABSTRACT

1. The effect of endotoxin on glucocorticoid (GC) induction of liver TO and TAT was investigated. 2. It was found that endotoxin inhibited not only TO GC induction, but also that of TAT, though to a lesser extent (17.41%). 3. Endotoxin did not influence the binding capacity of liver cytosol for 3H-dexamethasone at the second hour after the toxin administration. 4. In in vivo experiments endotoxin inhibited with 57.2% the binding of 3H-dexamethasone to hepatic nuclei. 5. It is suggested that the lower extent of endotoxin inhibition of GC induction of TAT may be due to the counteracting action of some inductor(s) for TAT only.

Subject(s)

Dexamethasone/metabolism , Endotoxins/pharmacology , Glucocorticoids/pharmacology , Liver/enzymology , Tryptophan Oxygenase/antagonists & inhibitors , Tyrosine Transaminase/antagonists & inhibitors , Adrenalectomy , Animals , Binding, Competitive , Cell Nucleus/metabolism , Cytosol/metabolism , Enzyme Induction/drug effects , Liver/drug effects , Liver/metabolism , Male , Rats , Rats, Inbred Strains , Tryptophan Oxygenase/biosynthesis , Tyrosine Transaminase/biosynthesis

2.

[Effect of intraventricular administration of 6-hydroxydopamine on the radiation stress induced increase in plasma corticosterone]. / Effekt intraventrikuliarnogo vvedeniia 6-gidroksidofamina na obuslovlennoe oblucheniem stressovoe povyshenie plazmaticheskogo kortikosterona

Popov, P G; Ankov, V K; Georgiev, V; Kavrakirova, S V; Belokonski, I S.

Radiobiologiia ; 15(6): 899-902, 1975.

Article in Russian | MEDLINE | ID: mdl-3822

Subject(s)

Corticosterone/blood , Hydroxydopamines/pharmacology , Radiation Injuries, Experimental/blood , Stress, Physiological/blood , Animals , Brain/metabolism , Dopamine/metabolism , Liver/enzymology , Male , Norepinephrine/metabolism , Rats , Sympathetic Nervous System/drug effects , Tyrosine Transaminase/metabolism , X-Rays

3.

Depressed synthesis of DNA in regenerating rat liver after spinal cord (C7) transection.

Vaptzarova, K I; Popov, P G; Veselý, J; Cihák, A.

Experientia ; 29(12): 1505-6, 1973 Dec.

Article in English | MEDLINE | ID: mdl-4772045

Subject(s)

DNA/biosynthesis , Liver Regeneration , Liver/metabolism , Spinal Cord/physiology , Animals , Carbon Radioisotopes , Denervation , Hepatectomy , Kinetics , Male , Rats , Thymine/metabolism

4.

Tyrosine-alpha-ketoglutarate aminotransferase activity in rat liver after spinal cord section.

Vaptzarova, K I; Popov, P G; Galabov, G P.

J Neurochem ; 21(2): 291-300, 1973 Aug.

Article in English | MEDLINE | ID: mdl-4146771

Subject(s)

Liver/enzymology , Spinal Cord/physiology , Tyrosine Transaminase/biosynthesis , Adrenal Glands/physiology , Adrenalectomy , Animals , Blood Glucose/metabolism , Carbon Isotopes , Corticosterone/blood , Cycloheximide/pharmacology , Dactinomycin/pharmacology , Enzyme Induction , Glucose/metabolism , Hydrocortisone/metabolism , Hydrocortisone/pharmacology , Hypophysectomy , Kinetics , Liver/metabolism , Male , Orotic Acid/metabolism , Peritoneum/metabolism , Pituitary Gland/physiology , Rats , Tritium

5.

Effect of olivomycin on the induced synthesis of tyrosine aminotransferase and tryptophan oxygenase in rat liver.

Popov, P G; Kavrakirova, S V; Maleev, A C.

Biochem Pharmacol ; 22(12): 1526-9, 1973 Jun 15.

Article in English | MEDLINE | ID: mdl-4147328

Subject(s)

Liver/enzymology , Olivomycins/pharmacology , Tryptophan Oxygenase/biosynthesis , Tyrosine Transaminase/biosynthesis , Adrenal Glands/physiology , Adrenalectomy , Animals , Ascorbic Acid/pharmacology , Drug Synergism , Enzyme Activation/drug effects , Female , Hydrocortisone/pharmacology , Liver/drug effects , Methemoglobin/pharmacology , Rats , Tryptophan/pharmacology

6.

Fluorometric study of tetracycline--bovine serum albumin interaction. The tetracyclines--a new class of fluorescent probes.

Popov, P G; Vaptzarova, K I; Kossekova, G P; Nikolov, T K.

Biochem Pharmacol ; 21(17): 2363-72, 1972 Sep 01.

Article in English | MEDLINE | ID: mdl-4630490

Subject(s)

Serum Albumin, Bovine , Tetracycline , Animals , Calcium/analysis , Cattle , Chlortetracycline , Chromatography , Drug Interactions , Edetic Acid , Fluorometry , Hydrogen-Ion Concentration , Magnesium/analysis , Mathematics , Methacycline , Oxytetracycline , Protein Binding , Solubility , Spectrum Analysis , Temperature , Thermodynamics , Zinc/analysis

7.

The effect of some cytostatics on tyrosine aminotransferase activity in rat liver.

Popov, P G; Kavrakirova, S V; Belokonsky, I S; Golovinsky, E V.

Acta Biol Med Ger ; 29(6): 751-5, 1972.

Article in English | MEDLINE | ID: mdl-4144760

Subject(s)

Antineoplastic Agents/pharmacology , Liver/enzymology , Tyrosine Transaminase/metabolism , Adrenalectomy , Animals , Cyclophosphamide/pharmacology , Female , Liver/drug effects , Liver/radiation effects , Mercaptopurine/pharmacology , Methotrexate/pharmacology , Radiation Effects , Rats , Time Factors , Tyrosine Transaminase/radiation effects

8.

Effect of irradiation on the biosynthesis of liver ribonucleic acids in intact and adrenalectomized rats.

Popov, P G; Valeva-Dimitrova, L I; Hadjiolov, A A.

Z Naturforsch B ; 26(12): 1282-7, 1971 Dec.

Article in English | MEDLINE | ID: mdl-4401882

Subject(s)

Adrenal Glands/physiology , Liver/radiation effects , RNA/biosynthesis , Radiation Effects , Adrenalectomy , Animals , Carbon Isotopes , Hydrocortisone/pharmacology , Liver/analysis , Liver/drug effects , Liver/physiology , Male , Orotic Acid/metabolism , RNA/isolation & purification , RNA/radiation effects , Rats , Rats, Inbred Strains , Starvation

9.

[Induced enzymes and ionizing radiation. 3. Effect of some radiation-protective agents on the tyrosine-alpha-ketoglutarate-aminotransferase activity in rat liver (a test for the rapid determination of radiation-protective effect)]. / Indutsiruemye énzimy i ioniziruiushchaia radiatsiia. 3. Izmenenia tirozin-al'fa-ketoglutarat-aminotransferaznoi aktivnosti v pecheni krys pod vliianiem nekotorykh radiozashchitnykh sredstv (ob odnom teste uskorennogo opredeleniia radiozashchitnogo deistviia.

Popov, P G; Belokonskii, I S.

Radiobiologiia ; 11(4): 495-8, 1971.

Article in Russian | MEDLINE | ID: mdl-4398795

Subject(s)

Liver/enzymology , Radiation Injuries, Experimental/prevention & control , Radiation-Protective Agents/therapeutic use , Tyrosine Transaminase/metabolism , Animals , Cystamine/therapeutic use , Cysteamine/therapeutic use , Enzyme Induction , Male , Rats , Serotonin/therapeutic use , Tryptamines/therapeutic use , beta-Aminoethyl Isothiourea/therapeutic use

10.

[Induced enzymes and ionizing radiation. 2. Changes in tyrosine-alpha-ketoglutarate-aminotransferase and N-demethylase activity in rat liver after irradiation]. / Indutsireumye énzimy i ioniziruiushchaia radiatsiia. 2. Izmenenie tirozin-alpha-ketoglutarat-aminotransferaznoi N-demetilaznoi aktivnosti v pecheni krys posle oblucheniia.

Popov, P G.

Radiobiologiia ; 11(2): 174-9, 1971.

Article in Russian | MEDLINE | ID: mdl-5092334

Subject(s)

Liver/radiation effects , Oxidoreductases/radiation effects , Radiation Effects , Transaminases/radiation effects , Aminopyrine , Animals , Ketoglutaric Acids , Liver/enzymology , Male , Methods , Oxidoreductases/biosynthesis , Rats , Time Factors , Transaminases/biosynthesis , Tyrosine

11.

[Induced enzymes and ionizing radiation. I. Changes in the activity of tryptophan pyrrolase in rats following irradiation]. / Indutsirovannye enzimy i ioniziruiushchaia radiatsiia. I. Izmenenie aktivnosti triptofanpirrolazy u krys posle oblucheniia.

Popov, P G; Ankov, V G.

Radiobiologiia ; 10(1): 32-6, 1970.

Article in Russian | MEDLINE | ID: mdl-5424068

Subject(s)

Radiation Injuries, Experimental/enzymology , Tryptophan Oxygenase/metabolism , Animals , Enzyme Induction , Male , Rats

12.

The effect of spinal cord section on rat liver tryptophan pyrrolase activity.

Vaptzarova, K I; Davidov, M S; Markov, D V; Popov, P G; Galabov, G P.

Life Sci ; 8(15): 905-9, 1969 Aug 01.

Article in English | MEDLINE | ID: mdl-5807321

Subject(s)

Liver/enzymology , Tryptophan Oxygenase/analysis , Adrenalectomy , Analysis of Variance , Animals , Enzyme Induction , Liver/innervation , Male , Rats , Spinal Cord/physiology

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