ABSTRACT
AIM: To analyze the role of consequences of combat stress in the development of gastrointestinal tract (GIT) diseases. SUBJECTS AND METHODS: One hundred and sixty-one combat veterans aged 24 to 69 years were examined. All underwent a clinical and neurological examination using the McGill pain questionnaire (MPQ), Beck depression inventory, Kotenev trauma stress questionnaire, and visual analogue scale to determine pain intensity. Anxiety, impairments in memory and sleep, and depression were identified. The SF-36 questionnaire was used to estimate quality of life in the patients. Gastric secretory function was investigated; esophagogastroduodenoscopy, X-ray and ultrasound studies, clinical and biochemical blood tests, coprological examinations, fecal tests for dysbiosis, if indicated, occult blood were made. RESULTS: Combat stress and its consequences as posttraumatic stress disorder have been shown to play an important role in the pathogenesis of GIT diseases and in the development of chronic abdominal pain. GIT diseases in combat veterans are in larger measure a sequel of impaired processes of adjustment to combat stress. Chronic abdominal pains were heterogeneous. On the one hand, chronic GIT disease serves as a source of pain syndrome; on the other hand, the central nervous system is of importance in the development of chronic abdominal pain. CONCLUSION: In addition to therapy for GIT and hepatobiliary diseases, the treatment of GIT diseases in this category of patients involves psychotherapy and neuroprotection, aimed at reducing the consequences of combat stress in combat veterans.
Subject(s)
Abdominal Pain/etiology , Combat Disorders/complications , Gastrointestinal Diseases/etiology , Veterans/psychology , Abdominal Pain/diagnosis , Abdominal Pain/physiopathology , Adult , Aged , Chronic Disease , Combat Disorders/diagnosis , Combat Disorders/physiopathology , Female , Gastrointestinal Diseases/diagnosis , Gastrointestinal Diseases/physiopathology , Humans , Male , Middle Aged , Russia , Surveys and Questionnaires , Young AdultABSTRACT
The paper presents the results of investigating an association between the frequency of chromosome aberrations and the CYP1A1, CYP1A2*1F GSTM1, and GSTT1 genes involved in xenobiotic biotransformation in workers engaged in heat and power engineering. The group of workers is shown to have a significantly higher rate of metaphases with aberrations (4.03 +/- 0.17%; n = 231) than the control group (2.06 +/- 0.17%; n = 141). Cytogenetic disorders are not found to depend on gender, age, and length of service. The study indicated that the level of chromosome aberrations was significantly higher in carriers of the CTP1A1 C/C, GSTM1 0/0 and GSTT1 0/0 genotypes. In individuals with a combination of the GSTM1 0/0 and GSTT1 0/0 genotypes, the level of chromosome aberrations was ascertained to be significantly higher than that in those with the protective form of these genes.
Subject(s)
Chromosome Aberrations , Genome, Human , Polymorphism, Genetic , Power Plants , Workplace/standards , Adult , Biotransformation/genetics , Case-Control Studies , Chromosome Aberrations/chemically induced , Chromosome Aberrations/statistics & numerical data , Data Interpretation, Statistical , Genotype , Humans , Mutagens/pharmacokinetics , Mutagens/toxicity , Occupational Exposure/adverse effects , Xenobiotics/pharmacokinetics , Xenobiotics/toxicityABSTRACT
A method of dosed compressive loads with a simultaneous registration of linear blood flow rate in the femoral artery was used in 32 healthy people and 30 patients with different localization of atherosclerotic process in major vessels with the help of an ultrasound apparatus of Bi-Doppler class and specific blood filling of lower extremities by the method of tetrapolar rheography. It was shown that most sensitive and objective index for the assessment of major and collateral blood circulation is a decrease or absence of the retrograde blood flow.
