ABSTRACT
The article describes, from the perspective of new regulations, the procedure of state registration of medical (dental) of products, acting on the territory of the Russian Federation.
Subject(s)
Device Approval/legislation & jurisprudence , Drug Approval/legislation & jurisprudence , Legislation, Dental/standards , Guidelines as Topic , RussiaABSTRACT
The article considers the practical aspects of the organization of the pharmacovigilance of medicines at the level of healthcare institutions.
Subject(s)
Adverse Drug Reaction Reporting Systems , Drug Monitoring , Health Facilities , Pharmacovigilance , Humans , RussiaABSTRACT
The paper reviews legislation base considering requirements for oral hygiene means in Russian Federation.
Subject(s)
Dentifrices/standards , Oral Hygiene/standards , Safety/legislation & jurisprudence , Humans , RussiaABSTRACT
Technical guidelines and voluntary standards are introduced in Russia since 2003. The paper contains the analysis of advantages and disadvantages of the new system for oral hygiene means registration.
Subject(s)
Drug Approval , Guidelines as Topic , Oral Hygiene/standards , Humans , RussiaABSTRACT
Nowadays an individual selection of personal care depending on the dental and hygiene human status is of great importance. The present study examines the clinical efficacy of toothbrushes with different characteristics of the brush field. The cleaning efficiency of toothbrushes with horizontal slant bristle and smooth cutting of the brush field is 75%, toothbrushes with a horizontal slant bristle and multilevel cutting of the brush field - 79%, toothbrushes with power bulge - 70% and toothbrushes with a flat brush field - 56%.
Subject(s)
Dental Devices, Home Care , Dental Plaque/prevention & control , Toothbrushing/instrumentation , Female , Humans , Male , Oral Hygiene Index , Surface PropertiesABSTRACT
Nocturnal symptoms are integral part of the general clinical picture of Parkinson's disease (PD). They are subdivided into non-motor and motor symptoms, the latter included night akinesia, crampi, night akathisia, dystonia, restless leg syndrome (RLS), periodic movements of limbs (PML) and psychomotor agitation during sleep. We have studied 53 patients with PD and evaluated the frequency of these disturbances as follows: night akinesia (42.7%), crampi (31.1%), night akathisia (7.8%), RLS (5.8%), PML (3.8%). The symptoms were treated with the three-component drug stalevo in a single dose in the evening during 3 months. The dose was equivalent to that of levodopa prescribed to the patient earlier in the composition of a two-component drug. The significant reduction of nocturnal motor symptoms with the respective decrease in the frequency of emotional disorders, the improvement of daily activities and quality of life of patients were seen after the treatment.
Subject(s)
Antiparkinson Agents/therapeutic use , Carbidopa/therapeutic use , Catechols/therapeutic use , Dopamine Agents/therapeutic use , Levodopa/therapeutic use , Parkinson Disease/drug therapy , Sleep Disorders, Intrinsic/drug therapy , Aged , Antiparkinson Agents/administration & dosage , Carbidopa/administration & dosage , Catechols/administration & dosage , Dopamine Agents/administration & dosage , Drug Combinations , Female , Humans , Levodopa/administration & dosage , Male , Middle Aged , Parkinson Disease/physiopathology , Sleep Disorders, Intrinsic/physiopathologyABSTRACT
The examination of hard tissues, periodontal and hygiene indices was conducted in 56 patients to determine the efficacy of toothpastes with natural compounds. According to the results, the natural compounds did not alter the color of the hard tissues, but also improved the hygienic status and lessened the periodontal inflammation manifestation in the oral cavity.
Subject(s)
Biological Products/administration & dosage , Oral Hygiene/methods , Periodontal Diseases/epidemiology , Toothpastes/administration & dosage , Female , Humans , Male , Oral Hygiene Index , Periodontal Diseases/prevention & control , Periodontal Index , Young AdultABSTRACT
The authors validate the necessity of microbiological control when certifying oral hygiene means. Results of microbiological expert evaluations of tooth pastes, gels, rinsing solutions, and other means are analyzed.
