ABSTRACT
A young adult male was referred for a second opinion of deranged liver biochemistry. He initially presented two years prior with abdominal pain, lethargy and fevers due to a segment two pyogenic liver abscess. He received empirical antibiotic therapy to resolution. Computed tomography for abscess follow-up revealed an intrahepatic inferior vena cava thrombus. He was anti-coagulated with warfarin. He was lupus anticoagulant positive and had a highly positive beta-2 glycoprotein antibody on serial measurement and was diagnosed with anti-phospholipid syndrome. On current review, the patient had no clinical stigmata of chronic liver disease. There were dilated veins on the supraumbilical abdominal and chest walls. There was mild hepatomegaly but no splenomegaly. Laboratory investigations revealed mildly cholestatic liver function tests with hyperbilirubinaemia (40µmol/L) but no liver synthetic dysfunction. Serological screening did not reveal any cause of chronic liver disease. The patient underwent multiphase abdominal CT and formal hepatic venography. What is the diagnosis and describe the hepatic venous outflow?
Subject(s)
Budd-Chiari Syndrome , Hepatic Veins , Humans , Liver Function Tests , Male , Tomography, X-Ray Computed , Young AdultABSTRACT
PURPOSE: Arterio-venous fistulae (AVFs) are accepted as the best form of haemodialysis vascular access (VA) but are plagued by high primary failure. Accessory drainage veins (ADVs) may account for up to 40% of these failures. Furthermore, they may also lead to low flow in 'mature' AVFs. METHODS: We analysed the results of 42 patients who underwent endovascular coiling of ADVs at our centre over a 4-year period. RESULTS: Indications were failure to mature in 34%, low flow or cannulation difficulty in 56% and thrombosis in 10% of cases. 95% procedures involved a combination of angioplasty and coiling with only 5% patients having coiling of ADV alone. Forearm AVFs constituted the majority of the cases as opposed to upper arm AVFs (74% vs. 26% respectively). Primary patency at 3, 6, 12, 18 and 24 months was 90%, 87%, 76%, 70% and 55% respectively. Successful dialysis was achieved in 10 of the 14 fistulae that had hitherto failed to mature. Coil migration was observed in 1 patient, which led to fistula occlusion. CONCLUSION: Coil embolisation of ADVs is an effective treatment option for dysfunctional fistulae that can be performed at the same time as angioplasty.
Subject(s)
Arteriovenous Shunt, Surgical/adverse effects , Embolization, Therapeutic , Renal Dialysis , Upper Extremity/blood supply , Adult , Aged , Aged, 80 and over , Angioplasty, Balloon , Blood Flow Velocity , Constriction, Pathologic , England , Female , Humans , Male , Middle Aged , Regional Blood Flow , Retrospective Studies , Time Factors , Treatment Failure , Vascular Patency , Veins/physiopathologyABSTRACT
The cornerstones of current management of deep vein thrombosis (DVT) are the routine use of anticoagulant therapy, graduated elastic compression stockings, and early ambulation. Thrombolytic therapy was previously reserved only for patients with life-, limb-, or organ-threatening complications. However, the postthrombotic syndrome has been increasingly recognized as a frequent and serious long-term complication of DVT. In parallel, endovascular thrombolytic methods have evolved considerably in recent years, prompting discussion and controversy as to whether they should be more liberally used. In some centers, pharmacomechanical catheter-directed thrombolysis is now routinely used in the treatment of acute iliofemoral DVT. Randomized trials are currently under way to determine when the use of pharmacomechanical catheter-directed thrombolysis is appropriate in patients presenting with acute proximal DVT.
Subject(s)
Blood Coagulation/drug effects , Endovascular Procedures , Fibrinolytic Agents/administration & dosage , Thrombolytic Therapy , Venous Thrombosis/drug therapy , Acute Disease , Endovascular Procedures/adverse effects , Evidence-Based Medicine , Fibrinolytic Agents/adverse effects , Hemorrhage/etiology , Humans , Patient Selection , Postthrombotic Syndrome/blood , Postthrombotic Syndrome/etiology , Postthrombotic Syndrome/prevention & control , Randomized Controlled Trials as Topic , Risk Assessment , Thrombolytic Therapy/adverse effects , Treatment Outcome , Venous Thrombosis/blood , Venous Thrombosis/complicationsABSTRACT
The pelvic course of the ureter with its close proximity to the iliac artery, pelvic viscera, and other structures predispose to fistula formation. Surgical management of lower urinary tract fistulas is difficult and often ineffective. Nonvascular lower urinary tract fistulas can be managed by urinary diversion with percutaneous nephrostomy to allow for fistula healing. If this fails, ureteral embolization can be very effective; however, this should be preceded by careful evaluation and discussion with the patient as this intervention results in irreversible ureteral occlusion necessitating a diverting nephrostomy catheter indefinitely. A ureteroarterial fistula is a distinct entity compared with nonvascular fistulas with a different approach to management; it can be managed by exclusion of the fistula by endovascular placement of a stent graft across the arterial component of the fistula.
