[The structural-functional properties of the thrombocytes in patients with a history of a myocardial infarct]. / Strukturno-funktsional'nye svoistva trombotsitov u bol'nykh, perenesshikh infarkt miokarda.

Functional state and morphological features of platelets were studied in patients with ischemic heart disease 3-24 months following the primary infarction and reinfarction. The studies made pointed to considerable changes in the structure, metabolism and reactivity of platelets. Chronic exposure to irritant factors makes for the depletion and destabilization of blood plates, their adhesive properties and ability to store and catabolize biogenic amines being upset, the destructive changes of glycocalix having a most pronounced impact on the platelet reactivity. The structural and functional disturbances revealed in the thrombocyte homeostasis have been found to correlate with the clinical course of the illness.

[Structural and functional characteristics of thrombocytes in chronic ischemic heart disease]. / Strukturno-funktsionalnoe sostoianie trombotsitov pri khronicheskoi ishemicheskoi bolezni serdtsa.

Platelets from 103 patients with chronic coronary heart disease were studied electron microscopically, cytochemically, fluorescence microscopically and with radionuclides. The platelets showed polymorphism indicated by diverse sizes, various content of alpha-granules in platelets, emergence of degenerative hyperosmiophilic forms. Shorter life cycle of the platelets was observed in line with a compensatory increase in the number of their immature forms. Abundance of reversibly and irreversibly activated and degranulated cells impaired platelet aggregation. These changes entailed rearrangement of platelet glycocalyx. The findings evidence noticeable structural shifts in platelets which diminish their resistance to factors stimulating atherogenesis and underlying aggravations of coronary heart disease.