Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 2 de 2
Filter
Add more filters










Database
Language
Publication year range
1.
Neuropharmacology ; 165: 107909, 2020 03 15.
Article in English | MEDLINE | ID: mdl-31857091

ABSTRACT

At the present time, gut microbiota inspires great interest in the field of neuroscience as a function of its role in normal physiology and involvement in brain function. This aspect suggests a specific gut-brain pathway, mainly modulated by gut microbiota activity. Among the multiple actions controlled by microbiota at the brain level, neuronal plasticity and cognitive function represent two of the most interesting aspects of this cross-talk communication. We address the possible action of two-months implementation of gut Bifidobacteria using a mixture of three different strains (B-MIX) on hippocampal plasticity and related cognitive behavior in adult healthy Sprague Dawley rats. B-MIX treatment increases the hippocampal BDNF with a parallel gain in dendritic spines' density of hippocampal CA1 pyramidal neurons. Electrophysiological experiments revealed a significant increment of HFS-induced LTP formation on the CA1 hippocampal region in B-MIX treated rats. All these effects are accompanied by a better cognitive performance observed in B-MIX treated animals with no impairments in locomotion activity. Therefore, in adult rats, the treatment with different strains of bifidobacteria is able to markedly enhance neuronal plasticity and the CNS function influencing cognitive behavior, an effect that may suggest a potential therapeutic treatment in brain diseases associated with cognitive functions.


Subject(s)
Bifidobacterium/physiology , Hippocampus/microbiology , Learning/physiology , Neuronal Plasticity , Animals , Brain-Derived Neurotrophic Factor/metabolism , Dendritic Spines/microbiology , Dendritic Spines/physiology , Male , Memory/physiology , Pyramidal Cells/cytology , Pyramidal Cells/microbiology , Pyramidal Cells/physiology , Rats, Sprague-Dawley , Spatial Learning/physiology
2.
Horm Res ; 27(1): 1-6, 1987.
Article in English | MEDLINE | ID: mdl-3114115

ABSTRACT

The response of growth hormone (GH) to acute administration of GH-releasing hormone 1-40 (GHRH) was evaluated in 12 patients with Turner's syndrome and in 12 prepubertal or early pubertal girls. In 7 of 12 patients GHRH induced a definite increase (greater than 10 ng/ml) of plasma GH levels. In 5 patients there was a poor GH rise after GHRH administration (less than 10 ng/ml). Overall, the mean GH response of patients was significantly lower than that of normal girls. Five out of 7 patients with a 45 X,O karyotype had a reduced GH rise after GHRH, while all patients with non X,O karyotype (mosaicism and/or 46 X,iX) had a normal GH response to GHRH. Although the cause of short stature in patients with Turner's syndrome is most likely multifactorial, a reduced pituitary GH reserve, as documented by the reduced GH response to GHRH in some of our patients, may contribute to the growth impairment in this disorder.


Subject(s)
Growth Hormone-Releasing Hormone/therapeutic use , Peptide Fragments/therapeutic use , Turner Syndrome/drug therapy , Adolescent , Adult , Clonidine/therapeutic use , Female , Growth Hormone/blood , Humans , Levodopa/therapeutic use
SELECTION OF CITATIONS
SEARCH DETAIL
...