[Effects of rehabilitation on neurohumoral regulation of the lower esophageal sphincter in patients with gastroesophageal reflux disease]. / Vliianie vosstanovitel'nogo lecheniia na neirogumoral'nuiu reguliatsiiu nizhnego pishchevodnogo sfinktera bol'nykh gastroézofageal'noi refliuksnoi bolezn'iu.

The effects of acupuncture or SHF electromagnetic field in combination with iodine-bromine baths on neurohumoral regulation of the lower esophageal sphincter were studied in patients with gastroesophageal reflux disease. DMW-therapy in combination with iodine-bromine baths lowered initially elevated level of the vasoactive intestinal polypeptide (VIP) while acupuncture reduced initially elevated levels of gastrin and VIP. These results show pathogenetic validity of using acupuncture or SHF electromagnetic field in combination with iodine-bromine baths in patients with gastroesophageal reflux disease of the first or second degree.

[Regulation of the functional status of the lower esophageal sphincter with gastrointestinal hormones in cardiospasm and reflux esophagitis]. / Patofiziologicheskie aspekty reguliatsii funktsional'nogo sostoianiia nizhnego pishchevodnogo sfinktera gastrointestinal'nymi gormonami pri kardiospazme i refliuks-ézofagite.

A role of gastrointestinal hormones in the regulation of the lower esophageal sphincter was studied in 22 patients with cardiospasm and 21 with reflux esophagitis. The levels of gastrin, vasoactive intestinal polypeptide (VIP), glucagon, insulin, and c peptide were determined by radioactive assay before and after surgical treatment. In opposite abnormalities (cardiospasm and reflux esophagitis), there is a different degree of VIP secretion both at the beginning and after functional exercises. Before and after functional exercises, the level of VIP was higher than in those with cardiospasm. The value of VIP on fasting and after functional exercises may be an additional information to establish the diagnoses of cardiospasm and reflux esophagitis and to evaluate the efficiency of the treatment performed.

[The evaluation of the efficacy and safety of using nalbuphine hydrochloride (Nubain) in patients in the early postoperative period]. / Otsenka éffektivnosti i bezopasnosti primeneniia nalbufina gidrokhlorida (nubaina) u bol'nykh v rannem posleoperatsionnom periode.

Nubaine (N) was used in 92 patients operated on the lungs, heart and major vessels, abdominal organs. N at a dose of 0.3 mg/kg caused adequate analgesia in 62-85% of cases on days 1-3 after surgery; it is an effective analgesic among those used in patients with acute postoperative pain. The effect of N on circulation, respiration, gas exchange, metabolism, and hormonal status was studied. It has been shown that N is a safe agent which has no considerable effect on respiration, hemodynamics, blood gas composition, and metabolism. In patients at high risk analgesia with N caused no serious side effects.