Diagnosis of the mechanisms of different types of discordances between phylogenies inferred from nuclear and mitochondrial markers.

In ancient freshwater lakes, an abnormally large species diversity is observed. The mechanisms that generated extremely high biodiversity in the ancient lakes have not been sufficiently studied and remain only partially known. Sequences of environmental changes in highly complex ecosystems such as Lake Baikal, may induce sophisticated combinations of microevolutionary processes. These processes are likely to result in unusual "patterns" of genetic variability of species. The most unusual patterns include the ones when speciation is followed by incomplete lineage sorting as well as mitochondrial or nuclear introgression. All these phenomena are diagnosed by comparing the topologies of phylogenetic trees inferred from molecular markers of evolution located in mitochondria and nuclei. Mitochondrial and nuclear introgression is a particularly interesting and complex case, which is the process of incorporating the gene alleles of one species into the gene pool of a sister species due to interspecific hybridization (introgressive hybridization). In many cases, existing methods for molecular phylogenetic analysis do not automatically allow the observed patterns of polymorphism to be explained and, therefore, cannot provide hypotheses that would explain the mechanisms which resulted to these patterns. Here we use adaptive dynamics models to study neutral molecular evolution under various scenarios of interaction between sister species and the environment. We propose and justify a set of criteria for detecting how two evolutionary trees may differ, with a special focus on comparing a tree inferred from nuclear DNA to one from mitochondrial DNA. The criteria react to branching pattern and branch lengths, including relative distances from ancestral lineages. Simulations show that the criteria allow fast and automated detection of various types of introgression, secondary breaches of reproductive barriers, and incomplete lineage sorting.

[The initial period in the formation of cardiac resuscitation service at the A. N. Bakulev Research Center of Cardiovascular Surgery, Russian Academy of Medical Sciences (1948-1973)].

The paper describes and analyzes the initial period in the formation of cardiac resuscitation service at the A. N. Bakulev Research Center of Cardiovascular Surgery, Russian Academy of Medical Sciences, from the first heart operation performed in the USSR to the setting up of the resuscitation-anesthesiology department. On September 24, 1948, A. N. Bakulev was the first in the USSR to make an operation for congenital heart disease, the successful outcome of which predetermined anesthetic maintenance and antishock measures as well. On May 1959, the Institute of Thoracic Surgery, U.S.S.R. Academy of Medical Sciences, began performing heart operations under extracorporeal circulation. The number of postoperative complications has increased due to the higher severity of diseases and the complexity of open heart surgery. This has made the rehabilitative period require that vital function recovery specialists should participate more frequently (Smirenskaya Ye. M.), which ultimately give birth to a resuscitation department in January 1967 (Levant A. D.) and its transformation to a resuscitation-anesthesiology department on October 31, 1973 (Malyshev V. D.).

Formation of supramolecular aggregations of gamma-globulin as a metal-dependent process.

The presence of copper cations in the solution of human serum gamma-globulin induced the formation of supramolecular forms of the protein. The intensity of this reaction increased with increasing copper concentration. The mechanisms of g-globulin aggregate formation under normal conditions and the possible role of bivalent metal cations in the regulation of protein effector functions are discussed.