[Long-term evaluation of immunosuppressive therapy in childhood idiopathic pulmonary hemosiderosis]. / Valutazione a lungo termine della terapia immunosoppressiva nella emosiderosi polmonare idiopatica dell'infanzia.

Idiopathic pulmonary hemosiderosis (IPM) is a rare disease of unknown etiology, whose diagnostic, prognostic and therapeutic approach is still open to discussion. In this paper the authors report a study regarding three cases of IPH initially detected in 13, 11 and 7 year-old children. The patients were treated with cyclophosphamide and prednisone according to different cycles depending on the clinical stage in the disease. All three patients are still alive after 10, 6 and 5 years since initial diagnosis. This therapeutic protocol therefore seems to be effective in preventing the progression of IPH and in maintaining the patients in an asymptomatic condition.

[Average number of bleeding episodes in hemophilic children of different ages in "on demand" therapy]. / Incidenza media di episodi emorragici nelle varie età del bambino emofilico in terapia "on demand".

We have studied the number of important bleeds in our patients with respect to the age group in order to find criteria for putting the hemophilic child on an effective continuous prophylactic regime as early as possible. The bleeding sites are shown in the Tables. 48 children with severe hemophilia were studied. We observed an increase in bleeds with an increase in age. This increase in bleeds and their recurrence in preferential sites in a high percentage (48%) of these children indicate a higher exposure to trauma in part, and a gradual incipience of an arthro-miopathy as well. To avoid this occurring we propose beginning prophylactic treatment as early as possible.