Subject(s)
AMP-Activated Protein Kinases/genetics , DNA/genetics , Heart Conduction System/physiopathology , Mutation , Wolff-Parkinson-White Syndrome , AMP-Activated Protein Kinases/metabolism , Humans , Wolff-Parkinson-White Syndrome/enzymology , Wolff-Parkinson-White Syndrome/genetics , Wolff-Parkinson-White Syndrome/physiopathologySubject(s)
Heart Rupture, Post-Infarction/diagnosis , Inferior Wall Myocardial Infarction/diagnosis , Magnetic Resonance Imaging , Cardiac Surgical Procedures , Contrast Media , Echocardiography , Electrocardiography , Heart Aneurysm/diagnosis , Heart Aneurysm/etiology , Heart Rupture, Post-Infarction/etiology , Heart Rupture, Post-Infarction/physiopathology , Heart Rupture, Post-Infarction/surgery , Humans , Inferior Wall Myocardial Infarction/complications , Inferior Wall Myocardial Infarction/physiopathology , Male , Middle Aged , Mitral Valve Insufficiency/diagnosis , Mitral Valve Insufficiency/etiology , Predictive Value of Tests , Severity of Illness Index , Stroke Volume , Systole , Treatment Outcome , Ventricular Dysfunction, Left/diagnosis , Ventricular Dysfunction, Left/etiology , Ventricular Dysfunction, Left/physiopathology , Ventricular Function, LeftSubject(s)
AMP-Activated Protein Kinases/genetics , Accessory Atrioventricular Bundle/genetics , Atrioventricular Block/genetics , Hypertrophy, Left Ventricular/genetics , Mutation, Missense , Tachycardia, Supraventricular/genetics , Accessory Atrioventricular Bundle/diagnosis , Accessory Atrioventricular Bundle/etiology , Adolescent , Atrioventricular Block/diagnosis , Atrioventricular Block/etiology , Atrioventricular Block/therapy , Catheter Ablation , Echocardiography , Electrocardiography , Electrophysiology , Heart Conduction System/physiopathology , Humans , Hypertrophy, Left Ventricular/complications , Hypertrophy, Left Ventricular/diagnosis , Magnetic Resonance Imaging , Male , Pacemaker, Artificial , Tachycardia, Supraventricular/diagnosis , Tachycardia, Supraventricular/etiologyABSTRACT
Hypereosinophilic syndrome is characterized by unexplained hypereosinophilia involving different organ systems. The investigators present a patient diagnosed with hypereosinophilic syndrome in which cardiac magnetic resonance was pivotal in establishing the presence of cardiac involvement.
Subject(s)
Heart Diseases/diagnosis , Heart Diseases/etiology , Hypereosinophilic Syndrome/complications , Magnetic Resonance Imaging/methods , Aged , Contrast Media , Echocardiography , Female , HumansABSTRACT
It has been extensively demonstrated that an elevated heart rate is a modifiable, independent risk factor for cardiovascular events. A high heart rate increases myocardial oxygen consumption and reduces diastolic perfusion time. It can also increase ventricular diastolic pressures and induce ventricular arrhythmias. Critical care patients are prone to develop a stress induced cardiac impairment and consequently an increase in sympathetic tone. This in turn increases heart rate. In this setting, however, heart rate lowering might be difficult because the effects of inotropic drugs could be hindered by heart rate reducing drugs like beta-blockers. Ivabradine is a new selective antagonist of funny channels. It lowers heart rate, reducing the diastolic depolarization slope. Moreover, ivabradine is not active on sympathetic pathways, thus avoiding any interference with inotropic amines. We reviewed the literature available regarding heart rate control in critical care patients, focusing our interest on the use of ivabradine to assess the potential benefits of the drug in this particular setting.
