ABSTRACT
AIM: Examination of clinical polymorphism of chronic obstructive pulmonary diseases (COPD) in defects of oxalate metabolism to make diagnostic outpatient screening of the preclinical stage. MATERIAL AND METHODS: Diagnostic dysgenetic markers of respiratory oxalosis (RO)--red hair in monthers and 24-h oxaluria--were studied in 28 women and 7 men. 8 women (group 1) had diagnostic association, 7 women (group 2) had no hereditary marker, 13 women (group 3) had no signs of disturbed oxalate metabolism. In addition, families of group 1 patients were examined for preclinical signs of visceral oxalosis in close relatives (kinship degree I). A comparison was made of quantitative enzyme assay of registering 24-h oxaluria (Lartillot M. et Vogel G) and titration by G. A. Sivorinovsky. RESULTS: Group 1 COPD patients with mild disease had rather high 24-h oxaluria. In group 2 and 3 patients oxaluria was significantly lower. Dysgenetic markers--24-h oxaluria with the hereditary criterium--may be used in differential diagnosis of RO with its phenocopy having a more severe course at preclinical stage. Male relatives of kinship degree I had significant differences with group 1 patients in 24-h oxaluria, oxaluria was combined with clinical symptoms of acid, uratic diathesis. CONCLUSION: The enzyme assay of oxalate in 24-h urine in combination with hereditary marker is an adequate screening method for preclinical stage of RO. The presence of various clinical manifestations of visceral oxalosis--RO and acid, uratic diathesis in the family--may indicate clinical polymorphism of mutant gene.
Subject(s)
Hyperoxaluria/genetics , Lung Diseases, Obstructive/genetics , Oxalates/metabolism , Polymorphism, Genetic , Adult , Calorimetry , Diagnosis, Differential , Female , Genetic Markers , Humans , Hyperoxaluria/diagnosis , Lung Diseases, Obstructive/metabolism , Male , Middle Aged , Time FactorsSubject(s)
Bronchodilator Agents/therapeutic use , Diuretics/therapeutic use , Hyperoxaluria, Primary/drug therapy , Lung Diseases, Obstructive/drug therapy , Theophylline/therapeutic use , Diuresis/drug effects , Drug Evaluation , Female , Humans , Hyperoxaluria, Primary/physiopathology , Lung Diseases, Obstructive/physiopathology , Male , Middle Aged , Remission Induction , Respiration/drug effectsABSTRACT
The characteristics of nonspecific immunity were studied on an outpatient material of 80 non-smoking women aged 38-60 years, with manifestations of hereditary primary enzymopathy (hyperoxaluria syndrome). Hyperoxaluria was shown to be related to immunologic imbalance of some components of nonspecific resistance by the cellular and humoral type. In addition to biochemical differences, the group of patients with prognostically favourable chronic asthmatic bronchitis have got immunologic differences with the alternative group.
Subject(s)
Asthma/diagnosis , Bronchitis/diagnosis , Hyperoxaluria/diagnosis , Immunologic Deficiency Syndromes/diagnosis , Adult , Asthma/etiology , Asthma/immunology , Bronchitis/etiology , Bronchitis/immunology , Chronic Disease , Female , Humans , Hyperoxaluria/complications , Hyperoxaluria/immunology , Immunity, Innate , Immunologic Deficiency Syndromes/complications , Immunologic Deficiency Syndromes/immunology , Middle Aged , PrognosisABSTRACT
The paper is concerned with a possibility of the use of an additional anamnestic test for selection of a group at risk for bronchial asthma during mass screenings of the community. The authors made use of the data obtained during examination of over 700 persons aged 18 to 59 years, both healthy and afflicted with bronchial asthma of varying severity. The proposed additional test was compared with conventional methods used in the anamnestic screening. Status-metry was used to design a functional model of classification of patients suffering from mild and grave bronchial asthma. Using this model, the most informative signs could be selected among nine immunologic and anamnestic signs.
