Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Mater Sci Eng C Mater Biol Appl ; 94: 220-233, 2019 Jan 01.
Article in English | MEDLINE | ID: mdl-30423704

ABSTRACT

For best photosensitizer activity phthalocyanine dyes used in photodynamic therapy should be molecularly dispersed. Polyethylene glycol-block-polylactide derivatives presenting benzyl side-groups were synthesized to encapsulate a highly lipophilic phthalocyanine dye (AlClPc) and evaluate the effect of π-π interactions on the nanocarrier colloidal stability and dye dispersion. Copolymers with 0, 1, 2 and 6 mol% of benzyl glycidyl ether (BGE) were obtained via polyethylene glycol initiated ring-opening copolymerization of D,l-lactide with BGE. The block copolymers formed stable, monodisperse nanospheres with low in vitro cytotoxicity. AlClPc loading increased the nanosphere size and affected their colloidal stability. The photo-physical properties of the encapsulated dye, studied in batch and after separation by field flow fractionation, demonstrated the superiority of plain PEG-PLA over BGE-containing copolymers in maintaining the dye in its monomeric (non-aggregated) form in aqueous suspension. High dye encapsulation and sustained dye release suggest that these nanocarriers are good candidates for photodynamic therapy.


Subject(s)
Drug Carriers/chemistry , Indoles/pharmacology , Nanospheres/chemistry , Photosensitizing Agents/pharmacology , Polyesters/chemistry , Polyethylene Glycols/chemistry , Animals , Cell Death/drug effects , Cell Survival/drug effects , Chlorocebus aethiops , Indoles/chemistry , Isoindoles , Kinetics , Macrophages/cytology , Macrophages/drug effects , Macrophages/metabolism , Mice , Molecular Weight , Octanols/chemistry , Particle Size , Photosensitizing Agents/chemistry , Polyesters/chemical synthesis , Polyethylene Glycols/chemical synthesis , Proton Magnetic Resonance Spectroscopy , Spectrometry, Fluorescence , Spectrophotometry, Ultraviolet , Static Electricity , Vero Cells
SELECTION OF CITATIONS
SEARCH DETAIL
...